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Tymlos, Eladynos(abaloparatide)
Eladynos, Tymlos (abaloparatide) is a protein pharmaceutical. Abaloparatide was first approved as Eladynos on . It is used to treat pasteurellaceae, postmenopausal osteoporosis, and postmenopausal osteoporosis in the USA. It has been approved in Europe to treat osteoporosis and postmenopausal osteoporosis. The pharmaceutical is active against parathyroid hormone/parathyroid hormone-related peptide receptor.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
musculoskeletal diseasesD009140
nutritional and metabolic diseasesD009750
Trade Name
FDA
EMA
Tymlos
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Abaloparatide
Tradename
Company
Number
Date
Products
TYMLOSRadius HealthN-208743 RX2017-04-28
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
tymlosNew Drug Application2020-10-30
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
pasteurellaceae—D015661—
postmenopausal osteoporosisEFO_0003854D015663—
postmenopausal osteoporosisEFO_0003854D015663—
Agency Specific
FDA
EMA
Expiration
Code
ABALOPARATIDE, TYMLOS, RADIUS HEALTH INC
2025-12-19I-907
2024-09-20M-270
Patent Expiration
Patent
Expires
Flag
FDA Information
Abaloparatide, Tymlos, Radius Health Inc
112558422040-01-10U-3322
109962082038-04-30DP
RE494442031-04-28U-2009, U-3543
78037702031-04-28U-2009
81483332027-11-08DP
87483822027-10-03U-2009, U-3543
ATC Codes
H: Systemic hormonal preparations, excl. sex hormones and insulins
— H05: Calcium homeostasis
— H05A: Parathyroid hormones and analogues
— H05AA: Parathyroid hormones and analogues
— H05AA04: Abaloparatide
HCPCS
No data
Clinical
Clinical Trials
33 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Familial amyloid neuropathiesD028227E85.1—22——2
Amyloid neuropathiesD017772——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
CardiomyopathiesD009202EFO_0000318I42—1———1
Nervous system lead poisoning adultD020265—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—14————14
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Takotsubo cardiomyopathyD054549EFO_1002000I51.81————11
PolyneuropathiesD011115EFO_0009562A69.22————11
Hereditary amyloidosis transthyretin-relatedC567782————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameABALOPARATIDE
INNabaloparatide
Description
Abaloparatide (brand name Tymlos) is a parathyroid hormone-related protein (PTHrP) analog drug used to treat osteoporosis. Like the related drug teriparatide, and unlike bisphosphonates, it is an anabolic (i.e., bone growing) agent.
Classification
Protein
Drug classpeptides: parathyroid hormone related peptide
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)—
Identifiers
PDB—
CAS-ID247062-33-5
RxCUI1921069
ChEMBL IDCHEMBL3301581
ChEBI ID—
PubChem CID76943386
DrugBankDB05084
UNII IDAVK0I6HY2U (ChemIDplus, GSRS)
Target
Agency Approved
PTH1R
PTH1R
Organism
Homo sapiens
Gene name
PTH1R
Gene synonyms
PTHR, PTHR1
NCBI Gene ID
5745
Protein name
parathyroid hormone/parathyroid hormone-related peptide receptor
Protein synonyms
Parathyroid hormone 1 receptor, parathyroid hormone receptor 1, parathyroid hormone/parathyroid hormone-related protein receptor, PTH/PTHr receptor, PTH/PTHrP type I receptor, PTH1 receptor, seven transmembrane helix receptor
Uniprot ID
Q2M1U3
Mouse ortholog
Pth1r (19228)
parathyroid hormone/parathyroid hormone-related peptide receptor (Q80WU8)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 781 documents
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Safety
Black-box Warning
Black-box warning for: Tymlos
Adverse Events
Top Adverse Reactions
Mock data
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2,196 adverse events reported
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