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Verzenio, Verzenios(abemaciclib)
Verzenio, Verzenios (abemaciclib) is a small molecule pharmaceutical. Abemaciclib was first approved as Verzenio on 2017-09-28. It has been approved in Europe to treat breast neoplasms. It is known to target cyclin-dependent kinase 6 and cyclin-dependent kinase 4.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
neoplasmsD009369
skin and connective tissue diseasesD017437
Trade Name
FDA
EMA
Verzenio
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Abemaciclib
Tradename
Company
Number
Date
Products
VERZENIOEli LillyN-208716 RX2017-09-28
4 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
verzenioNew Drug Application2020-09-28
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
Expiration
Code
ABEMACICLIB, VERZENIO, ELI LILLY AND CO
2024-10-12I-877, NPP
Patent Expiration
Patent
Expires
Flag
FDA Information
Abemaciclib, Verzenio, Eli Lilly And Co
78552112029-12-15DS, DPU-1981, U-2132, U-2135, U-2251, U-3241, U-3242, U-3243, U-3265, U-3546
ATC Codes
L: Antineoplastic and immunomodulating agents
— L01: Antineoplastic agents
— L01E: Protein kinase inhibitors, antineoplastic and immunomodulating agents
— L01EF: Cyclin-dependent kinase (cdk) inhibitors
— L01EF03: Abemaciclib
HCPCS
No data
Clinical
Clinical Trials
173 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Breast neoplasmsD001943EFO_0003869C502635103669
Neoplasm metastasisD009362EFO_00097085231—10
Triple negative breast neoplasmsD0647261411—6
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369C8019131—129
Non-small-cell lung carcinomaD002289731——10
Prostatic neoplasmsD011471C61362——8
Male breast neoplasmsD018567112——4
LiposarcomaD008080—11——2
Urogenital neoplasmsD014565EFO_0003863D07——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Endometrial neoplasmsD016889EFO_000423025———7
Brain neoplasmsD001932EFO_0003833C7144———6
Colorectal neoplasmsD01517952———5
Castration-resistant prostatic neoplasmsD06412923———4
GlioblastomaD005909EFO_000051522———4
Squamous cell carcinoma of head and neckD00007719514———4
Non-hodgkin lymphomaD008228C85.921———3
Multiple myelomaD009101C90.022———3
Renal cell carcinomaD00229231———3
AdenocarcinomaD00023023———3
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—8————8
Pancreatic neoplasmsD010190EFO_0003860C253————3
Primary myelofibrosisD055728D47.42————2
GliomaD005910EFO_00005202————2
Myelodysplastic syndromesD009190D461————1
Myeloid leukemia acuteD015470C92.01————1
Hematologic neoplasmsD0193371————1
Precursor cell lymphoblastic leukemia-lymphomaD054198C91.01————1
B-cell chronic lymphocytic leukemiaD015451C91.11————1
Bcr-abl positive chronic myelogenous leukemiaD015464EFO_00003401————1
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Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameABEMACICLIB
INNabemaciclib
Description
Abemaciclib, sold under the brand name Verzenio among others, is a medication for the treatment of advanced or metastatic breast cancers. It was developed by Eli Lilly and it acts as a CDK inhibitor selective for CDK4 and CDK6.
Classification
Small molecule
Drug classcyclin dependent kinase inhibitors (formerly-cidib)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1
Identifiers
PDB—
CAS-ID1231929-97-7
RxCUI1946825
ChEMBL IDCHEMBL3301610
ChEBI ID—
PubChem CID46220502
DrugBankDB12001
UNII ID60UAB198HK (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
CDK6
CDK6
CDK4
CDK4
Organism
Homo sapiens
Gene name
CDK6
Gene synonyms
CDKN6
NCBI Gene ID
1021
Protein name
cyclin-dependent kinase 6
Protein synonyms
Cell division protein kinase 6, Serine/threonine-protein kinase PLSTIRE
Uniprot ID
Q00534
Mouse ortholog
Cdk6 (12571)
cyclin-dependent kinase 6 (Q9R1D3)
Variants
Clinical Variant
No data
Financial
Verzenio - Eli Lilly
$
€
£
₣
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 3,505 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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