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Aceclidine
Aceclidine is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target muscarinic acetylcholine receptor M5, muscarinic acetylcholine receptor M1, muscarinic acetylcholine receptor M3, muscarinic acetylcholine receptor M4, and muscarinic acetylcholine receptor M2.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01E: Antiglaucoma preparations and miotics
— S01EB: Parasympathomimetics, antiglaucoma preparations and miotics
— S01EB08: Aceclidine
— S01EB58: Aceclidine, combinations
HCPCS
No data
Clinical
Clinical Trials
4 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PresbyopiaD011305H52.4—31——4
Refractive errorsD012030EFO_0003908H52.7—21——3
Eye diseasesD005128EFO_0003966H44—21——3
MiosisD015877HP_0000616H57.03—11——2
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameACECLIDINE
INNaceclidine
Description
Acetic acid 1-azabicyclo[2.2.2]octan-3-yl ester is a member of quinuclidines.
Classification
Small molecule
Drug classmuscarinic receptor agonists/antagonists
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(=O)OC1CN2CCC1CC2
Identifiers
PDB—
CAS-ID827-61-2
RxCUI—
ChEMBL IDCHEMBL20835
ChEBI ID—
PubChem CID1979
DrugBankDB13262
UNII ID0578K3ELIO (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
CHRM5
CHRM5
CHRM1
CHRM1
CHRM3
CHRM3
CHRM4
CHRM4
CHRM2
CHRM2
Organism
Homo sapiens
Gene name
CHRM5
Gene synonyms
NCBI Gene ID
1133
Protein name
muscarinic acetylcholine receptor M5
Protein synonyms
acetylcholine receptor, muscarinic 5
Uniprot ID
Q96RG7
Mouse ortholog
Chrm5 (213788)
muscarinic acetylcholine receptor M5 (Q920H4)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 63 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1 adverse events reported
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