Ademetionine
Ademetionine is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Clinical
Clinical Trials
143 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | — | — | 1 | 3 | 4 |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | — | 1 | 1 | 2 | 4 |
| Human influenza | D007251 | EFO_0007328 | J11.1 | — | — | — | 2 | — | 2 |
| Cardiac arrhythmias | D001145 | EFO_0004269 | I49.9 | — | — | — | 1 | 1 | 2 |
| Biliary liver cirrhosis | D008105 | K74.3 | — | 1 | — | 1 | — | 2 | |
| Knee injuries | D007718 | — | — | — | 1 | — | 1 | ||
| Pneumococcal infections | D011008 | EFO_0000772 | J13 | — | — | — | 1 | — | 1 |
| Vaccination | D014611 | EFO_0004292 | Z24 | — | — | — | 1 | — | 1 |
| Chickenpox | D002644 | EFO_0007204 | B01 | — | — | — | 1 | — | 1 |
| Hepatitis b | D006509 | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Depression | D003863 | F33.9 | — | 2 | 1 | — | 4 | 6 | |
| Hiv | D006678 | O98.7 | 1 | — | 1 | — | 2 | 4 | |
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | 2 | 1 | — | 1 | 3 |
| Alcoholic liver diseases | D008108 | EFO_0008573 | K70 | — | — | 1 | — | 1 | 2 |
| Tobacco use disorder | D014029 | F17 | — | 1 | 1 | — | 1 | 2 | |
| Hepatitis c | D006526 | B19.2 | — | 1 | 1 | — | — | 1 | |
| Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | — | — | 1 | — | — | 1 |
| Intrahepatic cholestasis | D002780 | — | — | 1 | — | — | 1 | ||
| Hepatitis | D006505 | HP_0012115 | K75.9 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 1 | 1 | — | — | 1 | 3 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | 1 | 1 | — | — | — | 2 |
| Hepatocellular carcinoma | D006528 | C22.0 | — | 1 | — | — | — | 1 | |
| Chronic hepatitis c | D019698 | EFO_0004220 | B18.2 | — | 1 | — | — | — | 1 |
| Disease | D004194 | EFO_0000408 | R69 | — | 1 | — | — | — | 1 |
| Hot flashes | D019584 | — | 1 | — | — | — | 1 | ||
| Varicose ulcer | D014647 | — | 1 | — | — | — | 1 | ||
| Alcoholic liver cirrhosis | D008104 | EFO_1000802 | K70.3 | — | 1 | — | — | — | 1 |
| Alcoholic hepatitis | D006519 | EFO_1001345 | K70.1 | — | 1 | — | — | — | 1 |
| Fibromyalgia | D005356 | EFO_0005687 | M79.1 | — | 1 | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Joint diseases | D007592 | HP_0003040 | M12.9 | — | — | — | — | 5 | 5 |
| Neoplasms | D009369 | C80 | — | — | — | — | 4 | 4 | |
| Coronary artery disease | D003324 | I25.1 | — | — | — | — | 3 | 3 | |
| Postoperative pain | D010149 | G89.18 | — | — | — | — | 3 | 3 | |
| Anesthesia | D000758 | — | — | — | — | 2 | 2 | ||
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | — | — | — | 2 | 2 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | — | — | — | 2 | 2 |
| Anxiety | D001007 | EFO_0005230 | F41.1 | — | — | — | — | 2 | 2 |
| Colonoscopy | D003113 | — | — | — | — | 2 | 2 | ||
| Hip osteoarthritis | D015207 | EFO_1000786 | M16 | — | — | — | — | 2 | 2 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | ADEMETIONINE |
| INN | ademetionine |
| Description | S-Adenosyl methionine (SAM), also known under the commercial names of SAMe, SAM-e, or AdoMet, is a common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation. Although these anabolic reactions occur throughout the body, most SAM is produced and consumed in the liver. More than 40 methyl transfers from SAM are known, to various substrates such as nucleic acids, proteins, lipids and secondary metabolites. It is made from adenosine triphosphate (ATP) and methionine by methionine adenosyltransferase. SAM was first discovered by Giulio Cantoni in 1952.
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| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | C[S+](CC[C@H](N)C(=O)[O-])C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O |
Identifiers
| PDB | — |
| CAS-ID | 29908-03-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1088977 |
| ChEBI ID | 67040 |
| PubChem CID | 9865604 |
| DrugBank | — |
| UNII ID | 7LP2MPO46S (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
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Variants
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Trends
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Additional graphs summarizing 193 documents
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Safety
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Adverse Events
Top Adverse Reactions
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78 adverse events reported
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