Adenosine phosphate
Adenocard, Adenoscan (adenosine phosphate) is a small molecule pharmaceutical. Adenosine phosphate was first approved as Adenocard on 1989-10-30. It is known to target transient receptor potential cation channel subfamily M member 4.
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Therapeutic Areas
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Trade Name
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EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| adenosine | ANDA | 2023-06-21 |
Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
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HCPCS
Code | Description |
|---|---|
| J0153 | Injection, adenosine, 1 mg (not to be used to report any adenosine phosphate compounds) |
Clinical
Clinical Trials
132 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Coronary artery disease | D003324 | I25.1 | 2 | 1 | 10 | 3 | 8 | 23 | |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | 1 | 2 | 2 | 1 | 2 | 7 |
| Supraventricular tachycardia | D013617 | HP_0004755 | I47.1 | — | — | — | 1 | 3 | 4 |
| Acute coronary syndrome | D054058 | EFO_0005672 | — | — | — | 1 | 1 | 2 | |
| Percutaneous coronary intervention | D062645 | — | — | 1 | 1 | — | 2 | ||
| Asthma | D001249 | EFO_0000270 | J45 | — | — | — | 1 | — | 1 |
| Ventricular premature complexes | D018879 | I49.3 | — | — | — | 1 | — | 1 | |
| Hypertrophic cardiomyopathy | D002312 | EFO_0000538 | I42.1 | — | — | — | 1 | — | 1 |
| No-reflow phenomenon | D054318 | — | — | — | 1 | — | 1 | ||
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 5 | 4 | 1 | — | 4 | 13 |
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | 1 | 2 | — | 4 | 7 |
| Neoplasms | D009369 | C80 | 2 | 2 | 1 | — | — | 4 | |
| Coronary stenosis | D023921 | EFO_1000882 | — | — | 1 | — | 2 | 3 | |
| Stable angina | D060050 | I20.8 | — | — | 1 | — | — | 1 | |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | 1 | 1 | — | — | 1 |
| Inferior wall myocardial infarction | D056989 | EFO_1000983 | — | — | 1 | — | — | 1 | |
| Palliative care | D010166 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | 2 | 1 | — | — | 1 | 3 |
| Takotsubo cardiomyopathy | D054549 | EFO_1002000 | I51.81 | — | 2 | — | — | — | 2 |
| Lung neoplasms | D008175 | C34.90 | 1 | 1 | — | — | — | 2 | |
| St elevation myocardial infarction | D000072657 | — | 2 | — | — | — | 2 | ||
| Colorectal neoplasms | D015179 | 1 | 1 | — | — | — | 1 | ||
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | 1 | 1 | — | — | — | 1 |
| Esophageal neoplasms | D004938 | C15 | 1 | 1 | — | — | — | 1 | |
| Left ventricular dysfunction | D018487 | — | 1 | — | — | — | 1 | ||
| Salivary gland neoplasms | D012468 | EFO_0003826 | D11 | — | 1 | — | — | — | 1 |
| Urologic neoplasms | D014571 | C64-C68 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Triple negative breast neoplasms | D064726 | 2 | — | — | — | — | 2 | ||
| Inflammation | D007249 | 1 | — | — | — | 1 | 2 | ||
| Magnetic resonance imaging | D008279 | 1 | — | — | — | 1 | 2 | ||
| Ischemia | D007511 | EFO_0000556 | 1 | — | — | — | 1 | 2 | |
| Atrioventricular block | D054537 | I44.3 | 1 | — | — | — | — | 1 | |
| Vasodilation | D014664 | 1 | — | — | — | — | 1 | ||
| Vasoconstriction | D014661 | 1 | — | — | — | — | 1 | ||
| Vascular diseases | D014652 | EFO_0004264 | I77 | 1 | — | — | — | — | 1 |
| Leukemia | D007938 | C95 | 1 | — | — | — | — | 1 | |
| B-cell chronic lymphocytic leukemia | D015451 | C91.1 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Autism spectrum disorder | D000067877 | F84.0 | — | — | — | — | 4 | 4 | |
| Heart failure | D006333 | EFO_0003144 | I50 | — | — | — | — | 3 | 3 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | — | 3 | 3 |
| Reperfusion injury | D015427 | — | — | — | — | 2 | 2 | ||
| Cough | D003371 | HP_0012735 | R05 | — | — | — | — | 2 | 2 |
| Bronchiectasis | D001987 | HP_0002110 | J47 | — | — | — | — | 2 | 2 |
| Craniofacial abnormalities | D019465 | — | — | — | — | 2 | 2 | ||
| Arthrogryposis | D001176 | EFO_0003857 | Q74.3 | — | — | — | — | 2 | 2 |
| Chest pain | D002637 | HP_0100749 | R07.9 | — | — | — | — | 2 | 2 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | ADENOSINE PHOSPHATE |
| INN | adenosine phosphate |
| Description | Adenosine 5'-monophosphate is a purine ribonucleoside 5'-monophosphate having adenine as the nucleobase. It has a role as an EC 3.1.3.11 (fructose-bisphosphatase) inhibitor, an EC 3.1.3.1 (alkaline phosphatase) inhibitor, an adenosine A1 receptor agonist, a nutraceutical, a micronutrient, a fundamental metabolite and a cofactor. It is an adenosine 5'-phosphate and a purine ribonucleoside 5'-monophosphate. It is a conjugate base of an adenosine 5'-monophosphate(1+). It is a conjugate acid of an adenosine 5'-monophosphate(2-). |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]1O |
Target
Agency Approved
No data
Alternate
TRPM4
TRPM4
Organism
Homo sapiens
Gene name
TRPM4
Gene synonyms
LTRPC4
NCBI Gene ID
Protein name
transient receptor potential cation channel subfamily M member 4
Protein synonyms
Calcium-activated non-selective cation channel 1, Long transient receptor potential channel 4, LTrpC-4, LTrpC4, Melastatin-4
Uniprot ID
Mouse ortholog
Trpm4 (68667)
transient receptor potential cation channel subfamily M member 4 (Q811E2)
Variants
Clinical Variant
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Financial
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Trends
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Safety
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Adverse Events
Top Adverse Reactions
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1,026 adverse events reported
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