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Afoxolaner
Afoxolaner is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
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HCPCS
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Clinical
Clinical Trials
25 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Paroxysmal hemoglobinuriaD006457Orphanet_447D59.12212—16
Geographic atrophyD057092113——5
GlomerulonephritisD005921N05—21——3
Membranoproliferative glomerulonephritisD015432—21——3
Hemolytic anemia autoimmuneD000744EFO_1001264D59.10—11——2
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Macular degenerationD008268EFO_0001365H35.3021———2
Amyotrophic lateral sclerosisD000690EFO_0000253G12.21—1———1
Motor neuron diseaseD016472EFO_0003782G12.2—1———1
Iga glomerulonephritisD005922EFO_0004194—1———1
Membranous glomerulonephritisD015433EFO_0004254N03.2—1———1
Lupus nephritisD008181EFO_0005761—1———1
Ovarian neoplasmsD010051EFO_0003893C56—1———1
Endometrioid carcinomaD018269—1———1
Fallopian tube neoplasmsD005185—1———1
Acinar cell carcinomaD018267—1———1
Indications Phases 1
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Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameAFOXOLANER
INNafoxolaner
Description
Afoxolaner (INN) is an insecticide and acaricide that belongs to the isoxazoline chemical compound group.
Classification
Small molecule
Drug classantagonists of GABA (gamma-aminobutyric acid) regulated chloride channels, antiparasitic agents
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O=C(CNC(=O)c1ccc(C2=NOC(c3cc(Cl)cc(C(F)(F)F)c3)(C(F)(F)F)C2)c2ccccc12)NCC(F)(F)F
Identifiers
PDB—
CAS-ID1093861-60-9
RxCUI1442093
ChEMBL IDCHEMBL2219412
ChEBI ID—
PubChem CID25154249
DrugBankDB11369
UNII ID02L07H6D0U (ChemIDplus, GSRS)
Target
Agency Approved
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Alternate
No data
Variants
Clinical Variant
No data
Financial
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 257 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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10 adverse events reported
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