Campath , Mabcampath(alemtuzumab)
Campath, Lemtrada (alemtuzumab) is an antibody pharmaceutical. Alemtuzumab was first approved as Campath on 2001-05-07. It is used to treat b-cell chronic lymphocytic leukemia in the USA. It has been approved in Europe to treat b-cell chronic lymphocytic leukemia and multiple sclerosis. The pharmaceutical is active against CAMPATH-1 antigen.
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Commercial
Trade Name
FDA
EMA
Campath, Lemtrada
Drug Products
FDA
EMA
Reference product - 351(a)
Reference product - 351(a)
Interchangeable product - 351(k)
Interchangeable product - 351(k)
Biosimilar product - 351(k)
Biosimilar product - 351(k)
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
alemtuzumab, Campath , Genzyme Corporation | |||
| 2108-05-07 | Orphan excl. | ||
alemtuzumab, Lemtrada, Genzyme Corporation | |||
| 2108-05-07 | Orphan excl. | ||
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J0202 | Injection, alemtuzumab, 1 mg |
Clinical
Clinical Trials
304 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | 3 | 2 | 3 | 2 | 8 | 17 |
| Kidney transplantation | D016030 | 3 | 6 | 2 | 5 | 3 | 16 | ||
| Relapsing-remitting multiple sclerosis | D020529 | EFO_0003929 | — | 2 | 4 | 3 | — | 9 | |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 2 | 3 | — | 1 | — | 4 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | 2 | 2 | — | 2 | — | 4 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | 1 | 2 | — | 1 | — | 3 |
| Graft rejection | D006084 | — | 1 | — | 1 | 1 | 3 | ||
| Vasculitis | D014657 | EFO_0006803 | M31 | 1 | — | — | 1 | — | 2 |
| Chronic inflammatory demyelinating polyradiculoneuropathy | D020277 | EFO_1000868 | G61.81 | — | — | — | 1 | — | 1 |
| Granulomatosis with polyangiitis | D014890 | EFO_0005297 | M31.3 | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leukemia | D007938 | C95 | 10 | 38 | 2 | — | 3 | 44 | |
| B-cell chronic lymphocytic leukemia | D015451 | C91.1 | 7 | 28 | 2 | — | 5 | 38 | |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | 11 | 20 | 2 | — | 1 | 26 |
| Myelodysplastic syndromes | D009190 | D46 | 6 | 20 | 2 | — | — | 22 | |
| Aplastic anemia | D000741 | HP_0001915 | D61.9 | 2 | 10 | 1 | — | 2 | 13 |
| Myeloid leukemia acute | D015470 | C92.0 | 3 | 7 | 1 | — | — | 9 | |
| T-cell lymphoma peripheral | D016411 | C84.9 | 2 | 7 | 1 | — | — | 9 | |
| Thalassemia | D013789 | EFO_1001996 | D56 | — | 6 | 1 | — | 1 | 7 |
| Extranodal nk-t-cell lymphoma | D054391 | C86.0 | — | 3 | 1 | — | — | 4 | |
| Diamond-blackfan anemia | D029503 | D61.01 | 1 | 3 | 1 | — | — | 3 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | C85.9 | 9 | 24 | — | — | 2 | 30 | |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | C91.0 | 6 | 14 | — | — | 1 | 16 | |
| Non-hodgkin lymphoma | D008228 | C85.9 | 8 | 9 | — | — | 2 | 15 | |
| Hodgkin disease | D006689 | C81 | 3 | 11 | — | — | 1 | 12 | |
| Graft vs host disease | D006086 | D89.81 | 3 | 7 | — | — | 1 | 10 | |
| Myeloproliferative disorders | D009196 | D47.1 | 3 | 6 | — | — | 1 | 9 | |
| Multiple myeloma | D009101 | C90.0 | 4 | 9 | — | — | — | 9 | |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | 3 | 8 | — | — | — | 8 | |
| Lymphoproliferative disorders | D008232 | Orphanet_2442 | D47.9 | 2 | 7 | — | — | 1 | 8 |
| Hematologic neoplasms | D019337 | 4 | 5 | — | — | 1 | 7 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Melanoma | D008545 | 1 | — | — | — | — | 1 | ||
| Germ cell and embryonal neoplasms | D009373 | 1 | — | — | — | — | 1 | ||
| Gastrointestinal stromal tumors | D046152 | EFO_0000505 | C49.A | 1 | — | — | — | — | 1 |
| Rhabdoid tumor | D018335 | 1 | — | — | — | — | 1 | ||
| Ewing sarcoma | D012512 | EFO_0000173 | 1 | — | — | — | — | 1 | |
| Rhabdomyosarcoma | D012208 | 1 | — | — | — | — | 1 | ||
| Large cell carcinoma | D018287 | 1 | — | — | — | — | 1 | ||
| Wilms tumor | D009396 | 1 | — | — | — | — | 1 | ||
| Neuroepithelial neoplasms | D018302 | 1 | — | — | — | — | 1 | ||
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lysosomal storage diseases | D016464 | — | — | — | — | 1 | 1 | ||
| Hematopoietic stem cell transplantation | D018380 | — | — | — | — | 1 | 1 | ||
| Hemoglobin sc disease | D006450 | EFO_1001797 | D57.2 | — | — | — | — | 1 | 1 |
| Kidney neoplasms | D007680 | EFO_0003865 | C64 | — | — | — | — | 1 | 1 |
| B-cell lymphoma | D016393 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | ALEMTUZUMAB |
| INN | alemtuzumab |
| Description | Immunoglobulin G 1 (human-rat monodonal CAMPATH-1H 71-chain anti-human antigen CD52), disulfide with human-rat monoclonal CAMPATH-1H light chain, dimer |
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | >1CE1:H|PROTEIN (CAMPATH-1H:HEAVY CHAIN)
QVQLQESGPGLVRPSQTLSLTCTVSGFTFTDFYMNWVRQPPGRGLEWIGFIRDKAKGYTTEYNPSVKGRVTMLVDTSKNQ
FSLRLSSVTAADTAVYYCAREGHTAAPFDYWGQGSLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV
SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVE
>1CE1:L|PROTEIN (CAMPATH-1H:LIGHT CHAIN)
DIQMTQSPSSLSASVGDRVTITCKASQNIDKYLNWYQQKPGKAPKLLIYNTNNLQTGVPSRFSGSGSGTDFTFTISSLQP
EDIATYYCLQHISRPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ
ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR |
Identifiers
| PDB | 1BEY, 1BFO, 1CE1, 6OBD |
| CAS-ID | 216503-57-0 |
| RxCUI | 117055 |
| ChEMBL ID | CHEMBL1201587 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB00087 |
| UNII ID | 3A189DH42V (ChemIDplus, GSRS) |
Target
Agency Approved
CD52
CD52
Organism
Homo sapiens
Gene name
CD52
Gene synonyms
CDW52, HE5
NCBI Gene ID
Protein name
CAMPATH-1 antigen
Protein synonyms
Cambridge pathology 1 antigen, CD52, CD52 antigen (CAMPATH-1 antigen), CDw52, CDW52 antigen (CAMPATH-1 antigen), Epididymal secretory protein E5, epididymis secretory sperm binding protein Li 171mP, He5, HEL-S-171mP, Human epididymis-specific protein 5
Uniprot ID
Mouse ortholog
Cd52 (23833)
CAMPATH-1 antigen (Q64389)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 11,703 documents
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Safety
Black-box Warning
Black-box warning for: Campath, Lemtrada
Adverse Events
Top Adverse Reactions
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3,660 adverse events reported
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