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Lopurin, Duzallo(allopurinol)
Aloprim, Duzallo, Zyloprim (allopurinol) is a small molecule pharmaceutical. Allopurinol was first approved as Lopurin on 1982-01-01. It is used to treat gout in the USA. It has been approved in Europe to treat gout. The pharmaceutical is active against xanthine dehydrogenase/oxidase.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
musculoskeletal diseasesD009140
hereditary congenital and neonatal diseases and abnormalitiesD009358
nutritional and metabolic diseasesD009750
Trade Name
FDA
EMA
Aloprim, Zyloprim (generic drugs available since 1986-10-24, discontinued: Lopurin)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Allopurinol
Tradename
Company
Number
Date
Products
ZYLOPRIMCasper PharmaN-016084 RX1982-01-01
3 products, RLD
ALLOPURINOLAllerganN-018832 RX1984-09-28
1 products
ALLOPURINOLAllerganN-018877 RX1984-09-28
1 products
Show 3 discontinued
Allopurinol
+
Lesinurad
Tradename
Company
Number
Date
Products
DUZALLOIronwood PharmaceuticalsN-209203 DISCN2017-08-18
2 products, RLD
Hide discontinued
Allopurinol sodium
Tradename
Company
Number
Date
Products
ALOPRIMMylanN-020298 RX1996-05-17
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
allopurinolANDA2023-06-14
aloprimNew Drug Application2022-02-07
zyloprimNew Drug Application2022-08-08
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
goutEFO_0004274D006073M10
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Allopurinol / Lesinurad, Duzallo, Ironwood Pharms Inc
85464362032-02-29DP
99562052031-12-28U-2104
92161792031-08-01U-2104
83577132029-12-22DPU-2104
80844832029-08-17U-2104
85464372029-04-29U-2104
82833692028-11-26U-2104
101830122028-11-26U-2104
80036812025-08-25DP
ATC Codes
M: Musculo-skeletal system drugs
— M04: Antigout preparations
— M04A: Antigout preparations
— M04AA: Preparations inhibiting uric acid production
— M04AA01: Allopurinol
— M04AA51: Allopurinol, combinations
HCPCS
No data
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameALLOPURINOL
INNallopurinol
Description
Allopurinol is a medication used to decrease high blood uric acid levels. It is specifically used to prevent gout, prevent specific types of kidney stones and for the high uric acid levels that can occur with chemotherapy. It is taken by mouth or injected into a vein.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Oc1ncnc2[nH]ncc12
Identifiers
PDB—
CAS-ID315-30-0
RxCUI519
ChEMBL IDCHEMBL1467
ChEBI ID40279
PubChem CID2094
DrugBankDB00437
UNII ID63CZ7GJN5I (ChemIDplus, GSRS)
Target
Agency Approved
XDH
XDH
Organism
Homo sapiens
Gene name
XDH
Gene synonyms
XDHA
NCBI Gene ID
7498
Protein name
xanthine dehydrogenase/oxidase
Protein synonyms
xanthine oxidoreductase
Uniprot ID
Q4PJ16
Mouse ortholog
Xdh (22436)
xanthine dehydrogenase/oxidase (Q00519)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 16,834 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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