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Almotriptan
Axert (almotriptan) is a small molecule pharmaceutical. Almotriptan was first approved as Axert on 2001-05-07. It is used to treat migraine disorders in the USA. It is known to target 5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine receptor 1D.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Almotriptan malate
Tradename
Company
Number
Date
Products
AXERTJohnson & JohnsonN-021001 DISCN2001-05-07
2 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
almotriptanANDA2021-11-22
axertNew Drug Application2012-10-10
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
migraine disordersEFO_0003821D008881G43
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N02: Analgesics
— N02C: Antimigraine preparations
— N02CC: Selective serotonin (5ht1) agonists
— N02CC05: Almotriptan
HCPCS
No data
Clinical
Clinical Trials
8 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Migraine disordersD008881EFO_0003821G43——24—6
Migraine without auraD020326EFO_0005296G43.0———2—2
Migraine with auraD020325EFO_0005295G43.1———2—2
SinusitisD012852EFO_0007486J32———1—1
Secondary headache disordersD051271———1—1
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameALMOTRIPTAN
INNalmotriptan
Description
Almotriptan is an indole compound having a 2-(dimethylamino)ethyl group at the 3-position and a (pyrrolidin-1-ylsulfonyl)methyl group at the 5-position. It has a role as a non-steroidal anti-inflammatory drug, a serotonergic agonist and a vasoconstrictor agent. It is a member of indoles, a sulfonamide and a tertiary amine.
Classification
Small molecule
Drug classantimigraine agents (5-HT1 receptor agonists); sumatriptan derivatives
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CN(C)CCc1c[nH]c2ccc(CS(=O)(=O)N3CCCC3)cc12
Identifiers
PDB—
CAS-ID154323-57-6
RxCUI279645
ChEMBL IDCHEMBL1505
ChEBI ID520985
PubChem CID123606
DrugBankDB00918
UNII ID1O4XL5SN61 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
HTR1B
HTR1B
HTR1D
HTR1D
Organism
Homo sapiens
Gene name
HTR1B
Gene synonyms
HTR1DB
NCBI Gene ID
3351
Protein name
5-hydroxytryptamine receptor 1B
Protein synonyms
5-HT-1D-beta, 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled, S12, Serotonin 1D beta receptor, Serotonin receptor 1B
Uniprot ID
Q4VAY7
Mouse ortholog
Htr1b (15551)
5-hydroxytryptamine receptor 1B (P28334)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 541 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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69,440 adverse events reported
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