Alvelestat
Alvelestat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against neutrophil elastase.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
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HCPCS
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Clinical
Clinical Trials
17 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | 2 | 5 | — | — | — | 7 |
| Emphysema | D004646 | EFO_0000464 | J43 | — | 2 | — | — | — | 2 |
| Alpha 1-antitrypsin deficiency | D019896 | E88.01 | — | 2 | — | — | — | 2 | |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 1 | — | — | — | 1 |
| Insulin resistance | D007333 | EFO_0002614 | — | 1 | — | — | — | 1 | |
| Covid-19 | D000086382 | U07.1 | 1 | 1 | — | — | — | 1 | |
| Hematologic neoplasms | D019337 | 1 | 1 | — | — | — | 1 | ||
| Graft vs host disease | D006086 | D89.81 | 1 | 1 | — | — | — | 1 | |
| Bronchiolitis obliterans | D001989 | EFO_0007183 | 1 | 1 | — | — | — | 1 | |
| Bronchiectasis | D001987 | HP_0002110 | J47 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 2 | — | — | — | — | 2 | ||
| Pharmacokinetics | D010599 | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | ALVELESTAT |
| INN | alvelestat |
| Description | Alvelestat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against neutrophil elastase. |
| Classification | Small molecule |
| Drug class | enzyme inhibitors: elastase inhibitors |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | Cc1c(-c2ccnn2C)cc(C(=O)NCc2ccc(S(C)(=O)=O)cn2)c(=O)n1-c1cccc(C(F)(F)F)c1 |
Identifiers
| PDB | — |
| CAS-ID | 1240425-05-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3617964 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 6Y5629322X (ChemIDplus, GSRS) |
Target
Agency Approved
ELANE
ELANE
Organism
Homo sapiens
Gene name
ELANE
Gene synonyms
ELA2
NCBI Gene ID
Protein name
neutrophil elastase
Protein synonyms
Bone marrow serine protease, elastase 2, neutrophil, Elastase-2, granulocyte-derived elastase, HLE, Human leukocyte elastase, leukocyte elastase, Medullasin, PMN elastase, polymorphonuclear elastase, polymorphonuclear leukocyte elastase
Uniprot ID
Mouse ortholog
Elane (50701)
neutrophil elastase (Q61515)
Alternate
No data
Variants
Clinical Variant
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Financial
No data
Trends
PubMed Central
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Additional graphs summarizing 76 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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