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Amdinocillin
Coactin (amdinocillin) is a small molecule pharmaceutical. Amdinocillin was first approved as Coactin on 1984-12-21. It is used to treat bacterial infections, escherichia coli infections, gram-negative bacterial infections, klebsiella infections, and urinary tract infections in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
urogenital diseasesD000091642
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Amdinocillin
Tradename
Company
Number
Date
Products
COACTINRocheN-050565 DISCN1984-12-21
3 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
bacterial infections—D001424A49
escherichia coli infectionsEFO_1001318D004927B96.20
gram-negative bacterial infections—D016905—
klebsiella infectionsEFO_1001353D007710—
urinary tract infectionsEFO_0003103D014552N39.0
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
J: Antiinfectives for systemic use
— J01: Antibacterials for systemic use
— J01C: Beta-lactam antibacterials, penicillins
— J01CA: Penicillins with extended spectrum
— J01CA11: Mecillinam
HCPCS
No data
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameAMDINOCILLIN
INNmecillinam
Description
Mecillinam is a penicillin in which the 6beta substituent is [(azepan-1-yl)methylidene]amino; an extended-spectrum penicillin antibiotic that binds specifically to penicillin binding protein 2 (PBP2), and is only considered to be active against Gram-negative bacteria. It has a role as an antibacterial drug and an antiinfective agent.
Classification
Small molecule
Drug classpenicillins
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC1(C)S[C@@H]2[C@H](/N=C/N3CCCCCC3)C(=O)N2[C@H]1C(=O)O
Identifiers
PDB—
CAS-ID32887-01-7
RxCUI626
ChEMBL IDCHEMBL530
ChEBI ID—
PubChem CID36273
DrugBankDB01163
UNII IDV10579P3QZ (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,564 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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10 adverse events reported
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