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Amifostine
Ethyol (amifostine) is a small molecule pharmaceutical. Amifostine was first approved as Ethyol on 1995-12-08. It is used to treat experimental radiation injuries in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
wounds and injuriesD014947
investigative techniquesD008919
physical phenomenaD055585
Trade Name
FDA
EMA
Ethyol (generic drugs available since 2008-03-14)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Amifostine
Tradename
Company
Number
Date
Products
ETHYOLClinigenN-020221 RX1995-12-08
1 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
ethyolNew Drug Application2019-12-09
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
experimental radiation injuries—D011833—
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
V: Various drug classes in atc
— V03: All other therapeutic products
— V03A: All other therapeutic products
— V03AF: Detoxifying agents for antineoplastic treatment
— V03AF05: Amifostine
HCPCS
Code
Description
J0207
Injection, amifostine, 500 mg
Clinical
Clinical Trials
23 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
IleusD045823K56.7—15129
ConstipationD003248HP_0002019K59.0—231—6
Acute painD059787R52———1—1
Postoperative painD010149G89.18———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Urinary bladder neoplasmsD001749C67——1——1
Ovarian neoplasmsD010051EFO_0003893C56——1——1
Fallopian tube neoplasmsD005185——1——1
Peritoneal neoplasmsD010534——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369C80—2———2
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Ventral herniaD006555EFO_1001866K43————11
Spinal fusionD013123————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameAMIFOSTINE
INNamifostine
Description
Amifostine is an organic thiophosphate that is the S-phospho derivative of 2-[(3-aminopropyl)amino]ethanethiol. A prodrug for the free thiol, WR-1065, which is used as a cytoprotectant in cancer chemotherapy and radiotherapy. It has a role as a prodrug, a radiation protective agent and an antioxidant. It is a diamine and an organic thiophosphate. It is functionally related to a cysteamine.
Classification
Small molecule
Drug classphosphoro-derivatives
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
NCCCNCCSP(=O)(O)O
Identifiers
PDB—
CAS-ID20537-88-6
RxCUI1545987
ChEMBL IDCHEMBL1006
ChEBI ID2636
PubChem CID2141
DrugBankDB01143
UNII IDILA426L95O (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
Ethyol - Cumberland Pharmaceuticals
$
€
£
₣
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 3,112 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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298 adverse events reported
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