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Aminocaproic acid
Amicar (aminocaproic acid) is a small molecule pharmaceutical. Aminocaproic acid was first approved as Amicar on 1982-01-01. The pharmaceutical is active against plasminogen. In addition, it is known to target apolipoprotein(a).
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
Amicar (generic drugs available since 1987-03-09)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Aminocaproic acid
Tradename
Company
Number
Date
Products
AMICARAkornN-015197 RX1982-01-01
2 products, RLD
AMICARAkornN-015230 RX1982-01-01
1 products, RLD, RS
Show 2 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
amicarNew Drug Application2020-10-09
aminocaproic acidANDA2023-04-06
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
B: Blood and blood forming organ drugs
— B02: Antihemorrhagics
— B02A: Antifibrinolytics
— B02AA: Antifibrinolytic amino acids
— B02AA01: Aminocaproic acid
HCPCS
Code
Description
S0017
Injection, aminocaproic acid, 5 grams
Clinical
Clinical Trials
1 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
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Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameAMINOCAPROIC ACID
INNaminocaproic acid
Description
6-aminohexanoic acid is an epsilon-amino acid comprising hexanoic acid carrying an amino substituent at position C-6. Used to control postoperative bleeding, and to treat overdose effects of the thrombolytic agents streptokinase and tissue plasminogen activator. It has a role as an antifibrinolytic drug, a hematologic agent and a metabolite. It is an epsilon-amino acid and an omega-amino fatty acid. It is functionally related to a hexanoic acid. It is a conjugate acid of a 6-aminohexanoate. It is a tautomer of a 6-aminohexanoic acid zwitterion.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
NCCCCCC(=O)O
Identifiers
PDB3KIV
CAS-ID60-32-2
RxCUI99
ChEMBL IDCHEMBL1046
ChEBI ID16586
PubChem CID564
DrugBankDB00513
UNII IDU6F3787206 (ChemIDplus, GSRS)
Target
Agency Approved
PLG
PLG
Organism
Homo sapiens
Gene name
PLG
Gene synonyms
NCBI Gene ID
5340
Protein name
plasminogen
Protein synonyms
plasmin
Uniprot ID
Q6PA00
Mouse ortholog
Plg (18815)
plasminogen (Q91WJ5)
Alternate
LPA
LPA
Organism
Homo sapiens
Gene name
LPA
Gene synonyms
NCBI Gene ID
4018
Protein name
apolipoprotein(a)
Protein synonyms
antiangiogenic AK38 protein, apo(a), lipoprotein, Lp(a), lp(a)
Uniprot ID
Q9UD88
Mouse ortholog
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Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 5,985 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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118 adverse events reported
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