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Aminoglutethimide
Cytadren (aminoglutethimide) is a small molecule pharmaceutical. Aminoglutethimide was first approved as Cytadren on 1982-01-01. It is used to treat breast neoplasms, cushing syndrome, hormone-dependent neoplasms, and prostatic neoplasms in the USA. The pharmaceutical is active against aromatase. In addition, it is known to target cholesterol side-chain cleavage enzyme, mitochondrial.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
neoplasmsD009369
urogenital diseasesD000091642
skin and connective tissue diseasesD017437
endocrine system diseasesD004700
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Aminoglutethimide
Tradename
Company
Number
Date
Products
CYTADRENNovartisN-018202 DISCN1982-01-01
1 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
breast neoplasmsEFO_0003869D001943C50
cushing syndromeEFO_0003099D003480E24
hormone-dependent neoplasms—D009376—
prostatic neoplasms—D011471C61
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
L: Antineoplastic and immunomodulating agents
— L02: Endocrine therapy antineoplastic and immunomodulating agents
— L02B: Hormone antagonists and related agents
— L02BG: Aromatase inhibitors
— L02BG01: Aminoglutethimide
HCPCS
No data
Clinical
Clinical Trials
26 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
OsteoarthritisD010003EFO_0002506M15-M19———123
FibrinolysisD005342—111—2
HemorrhageD006470MP_0001914R58——11—2
ScoliosisD012600EFO_0004273M41———112
Oral hemorrhageD006472———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Cardiopulmonary bypassD002315—11—12
InflammationD007249—11——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
CraniosynostosesD003398Q75.011———2
Surgical blood lossD016063—1———1
Knee osteoarthritisD020370EFO_0004616M17—1———1
ThrombosisD013927—1———1
Hematologic neoplasmsD019337—1———1
ThrombocytopeniaD013921HP_0001873D69.6—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Cerebral hemorrhageD0025431————1
Aortic diseasesD0010181————1
RosaceaD012393L711————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Spinal stenosisD013130EFO_0007490M48.0————11
SpondylitisD013166M46.9————11
KyphosisD007738HP_0002808M40.20————11
LordosisD008141M40.5————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameAMINOGLUTETHIMIDE
INNaminoglutethimide
Description
Aminoglutethimide is a dicarboximide that is a six-membered cyclic compound having ethyl and 4-aminophenyl substituents at the 3-position. It has a role as an antineoplastic agent, an adrenergic agent, an EC 1.14.14.14 (aromatase) inhibitor and an anticonvulsant. It is a dicarboximide, a member of piperidones and a substituted aniline. It is functionally related to a piperidine-2,6-dione.
Classification
Small molecule
Drug classAromatase inhibitor; Antiestrogen; Steroidogenesis inhibitor; Antiglucocorticoid
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCC1(c2ccc(N)cc2)CCC(=O)NC1=O
Identifiers
PDB—
CAS-ID125-84-8
RxCUI—
ChEMBL IDCHEMBL488
ChEBI ID2654
PubChem CID2145
DrugBankDB00357
UNII ID0O54ZQ14I9 (ChemIDplus, GSRS)
Target
Agency Approved
CYP19A1
CYP19A1
Organism
Homo sapiens
Gene name
CYP19A1
Gene synonyms
ARO1, CYAR, CYP19
NCBI Gene ID
1588
Protein name
aromatase
Protein synonyms
CYPXIX, Cytochrome P-450AROM, Cytochrome P450 19A1, cytochrome P450, family 19, subfamily A, polypeptide 1, cytochrome P450, subfamily XIX (aromatization of androgens), Estrogen synthase, estrogen synthetase, flavoprotein-linked monooxygenase, microsomal monooxygenase
Uniprot ID
Q8IYJ7
Mouse ortholog
Cyp19a1 (13075)
aromatase (P28649)
Alternate
CYP11A1
CYP11A1
Organism
Homo sapiens
Gene name
CYP11A1
Gene synonyms
CYP11A
NCBI Gene ID
1583
Protein name
cholesterol side-chain cleavage enzyme, mitochondrial
Protein synonyms
cholesterol 20-22 desmolase, Cholesterol desmolase, cholesterol monooxygenase (side-chain cleaving), CYPXIA1, Cytochrome P450 11A1, cytochrome P450 family 11 subfamily A polypeptide 1, Cytochrome P450(scc), cytochrome P450, subfamily XIA (cholesterol side chain cleavage), steroid 20-22-lyase
Uniprot ID
Q8N1A7
Mouse ortholog
Cyp11a1 (13070)
cholesterol side-chain cleavage enzyme, mitochondrial (Q9QZ82)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,149 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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174 adverse events reported
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