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Amiodarone
Nexterone (amiodarone) is a small molecule pharmaceutical. Amiodarone was first approved as Cordarone on 1985-12-24. It is used to treat cardiac arrhythmias, supraventricular tachycardia, and ventricular fibrillation in the USA. It is known to target potassium voltage-gated channel subfamily A member 7, muscarinic acetylcholine receptor M5, sodium channel protein type 5 subunit alpha, and NAD-dependent protein deacetylase sirtuin-3, mitochondrial.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Nexterone (generic drugs available since 1998-04-30, discontinued: Cordarone)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Amiodarone hydrochloride
Tradename
Company
Number
Date
Products
NEXTERONEBaxterN-022325 RX2010-11-16
2 products, RLD, RS
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Labels
FDA
EMA
Brand Name
Status
Last Update
amiodarone hydrochlorideANDA2023-04-18
nexteroneNew Drug Application2016-11-22
paceroneANDA2020-09-24
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
cardiac arrhythmiasEFO_0004269D001145I49.9
supraventricular tachycardiaHP_0004755D013617I47.1
ventricular fibrillationEFO_0004287D014693I49.01
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Amiodarone Hydrochloride, Nexterone, Baxter Hlthcare
76357732029-03-13DP
ATC Codes
C: Cardiovascular system drugs
— C01: Cardiac therapy drugs
— C01B: Antiarrhythmics, class i and iii
— C01BD: Antiarrhythmics, class iii
— C01BD01: Amiodarone
HCPCS
Code
Description
J0282
Injection, amiodarone hydrochloride, 30 mg
Clinical
Clinical Trials
102 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Atrial fibrillationD001281EFO_0000275I48.0—519211660
Ventricular tachycardiaD017180I47.2—133411
Cardiac arrhythmiasD001145EFO_0004269I49.9—14139
Ventricular fibrillationD014693EFO_0004287I49.01——31—4
Heart failureD006333EFO_0003144I50——13—4
SepsisD018805A41.9——12—3
Septic shockD012772A48.3——12—3
CardiomyopathiesD009202EFO_0000318I42——11—2
Ventricular premature complexesD018879I49.3——11—2
TachycardiaD013610HP_0001649R00.0———112
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Heart diseasesD006331EFO_0003777I51.9——5—16
Heart arrestD006323EFO_0009492I46—13—15
Cardiovascular diseasesD002318EFO_0000319I98——4—15
Coronary artery diseaseD003324I25.11—2——3
Sudden death cardiacD016757EFO_0004278——2—13
Chagas cardiomyopathyD002598EFO_0005529——1—12
Atrial flutterD001282EFO_0003911—11——2
Ebola hemorrhagic feverD019142EFO_0007243A98.4—11——1
Covid-19D000086382U07.1—11——1
Implantable defibrillatorsD017147EFO_0010674——1——1
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Supraventricular tachycardiaD013617HP_0004755I47.1—1——23
Immunoglobulin light-chain amyloidosisD000075363—1———1
Blood pressureD001794EFO_0004325—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—2————2
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Myocardial ischemiaD017202EFO_1001375I20-I25————11
DeathD003643PATO_0001422————11
Out-of-hospital cardiac arrestD058687————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameAMIODARONE
INNamiodarone
Description
Amiodarone is a member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias. It has a role as a cardiovascular drug. It is a member of 1-benzofurans, an organoiodine compound, an aromatic ketone and a tertiary amino compound.
Classification
Small molecule
Drug classantiarrhythmics: indicates high iodine content
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCCCc1oc2ccccc2c1C(=O)c1cc(I)c(OCCN(CC)CC)c(I)c1
Identifiers
PDB4O8Z
CAS-ID1951-25-3
RxCUI703
ChEMBL IDCHEMBL633
ChEBI ID2663
PubChem CID2157
DrugBankDB01118
UNII IDN3RQ532IUT (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
KCNA7
KCNA7
CHRM5
CHRM5
SCN5A
SCN5A
SIRT3
SIRT3
Organism
Homo sapiens
Gene name
KCNA7
Gene synonyms
NCBI Gene ID
3743
Protein name
potassium voltage-gated channel subfamily A member 7
Protein synonyms
potassium channel, voltage gated shaker related subfamily A, member 7, potassium voltage-gated channel, shaker-related subfamily, member 7, voltage-dependent potassium channel Kv1.7, voltage-gated potassium channel KCNA7, Voltage-gated potassium channel subunit Kv1.7
Uniprot ID
Q9BYS4
Mouse ortholog
Kcna7 (16495)
potassium voltage-gated channel subfamily A member 7 (Q17ST2)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 25,157 documents
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Safety
Black-box Warning
Black-box warning for: Pacerone
Adverse Events
Top Adverse Reactions
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362,114 adverse events reported
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