Amphotericin b
Abelcet, Ambisome (amphotericin b) is a small molecule pharmaceutical. Amphotericin b was first approved as Fungizone on 1982-01-01. It is used to treat aids-related opportunistic infections, aspergillosis, blastomycosis, chronic mucocutaneous candidiasis, and coccidioidomycosis amongst others in the USA.
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Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
| digestive system diseases | D004066 |
| respiratory tract diseases | D012140 |
| nervous system diseases | D009422 |
| urogenital diseases | D000091642 |
| hemic and lymphatic diseases | D006425 |
| skin and connective tissue diseases | D017437 |
| immune system diseases | D007154 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
Abelcet, Ambisome (generic drugs available since 1992-04-29, discontinued: Amphotec, Fungizone)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| aids-related opportunistic infections | — | D017088 | — |
| aspergillosis | EFO_0007157 | D001228 | B44 |
| blastomycosis | EFO_0007174 | D001759 | B40 |
| chronic mucocutaneous candidiasis | Orphanet_1334 | D002178 | B37.2 |
| coccidioidomycosis | EFO_0007211 | D003047 | B38 |
| cryptococcal meningitis | EFO_0007228 | D016919 | B45.1 |
| cutaneous candidiasis | — | D002179 | — |
| cystitis | EFO_1000025 | D003556 | N30 |
| fungemia | — | D016469 | B49 |
| histoplasmosis | EFO_0007310 | D006660 | B39 |
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Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
— A01: Stomatological preparations
— A01A: Stomatological preparations
— A01AB: Antiinfectives and antiseptics for local oral treatment
— A01AB04: Amphotericin b
— A07: Antidiarrheals, intestinal antiinflammatory/antiinfective agents
— A07A: Intestinal antiinfectives
— A07AA: Antibiotics, intestinal
— A07AA07: Amphotericin b
G: Genito urinary system and sex hormones
— G01: Gynecological antiinfectives and antiseptics
— G01A: Antiinfectives and antiseptics, excl. combinations with corticosteroids
— G01AA: Antibiotics, gynecological
— G01AA03: Amphotericin b
J: Antiinfectives for systemic use
— J02: Antimycotics for systemic use
— J02A: Antimycotics for systemic use
— J02AA: Antibiotics for systemic use
— J02AA01: Amphotericin b
Clinical
Clinical Trials
130 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cryptococcal meningitis | D016919 | EFO_0007228 | B45.1 | 4 | 7 | 4 | 1 | 10 | 23 |
| Visceral leishmaniasis | D007898 | B55.0 | 1 | 4 | 7 | 3 | 1 | 16 | |
| Mycoses | D009181 | B35-B49 | — | 2 | 5 | 3 | 1 | 11 | |
| Invasive pulmonary aspergillosis | D055744 | B44.0 | 1 | 3 | 3 | 2 | — | 9 | |
| Candidiasis | D002177 | B37 | — | — | 4 | 1 | 1 | 6 | |
| Invasive candidiasis | D058365 | EFO_1001283 | B37 | — | 2 | 1 | 1 | — | 4 |
| Neutropenia | D009503 | D70 | — | 1 | 2 | 1 | — | 4 | |
| Liver transplantation | D016031 | EFO_0010682 | — | — | 1 | 1 | — | 2 | |
| Blastomycosis | D001759 | EFO_0007174 | B40 | — | — | 1 | 1 | — | 2 |
| Sepsis | D018805 | A41.9 | — | — | — | 1 | 1 | 2 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv infections | D015658 | EFO_0000764 | B20 | 2 | 4 | 5 | — | 8 | 18 |
| Aspergillosis | D001228 | EFO_0007157 | B44 | — | 3 | 3 | — | — | 5 |
| Infections | D007239 | EFO_0000544 | — | — | 3 | — | 1 | 4 | |
| Vulvovaginal candidiasis | D002181 | EFO_0007543 | B37.3 | — | 2 | 1 | — | — | 3 |
| Lung transplantation | D016040 | — | — | 3 | — | — | 3 | ||
| Allergic bronchopulmonary aspergillosis | D001229 | EFO_0007140 | B44.81 | — | 2 | 1 | — | — | 2 |
| Neoplasms | D009369 | C80 | — | — | 2 | — | — | 2 | |
| Bacterial vaginosis | D016585 | EFO_0003932 | — | — | 2 | — | — | 2 | |
| Myelodysplastic syndromes | D009190 | D46 | — | 1 | 1 | — | — | 2 | |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | — | 1 | 1 | — | — | 2 |
Show 9 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myeloid leukemia acute | D015470 | C92.0 | — | 4 | — | — | — | 4 | |
| Mucormycosis | D009091 | EFO_0007380 | B46.5 | — | 2 | — | — | — | 2 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | C91.0 | — | 2 | — | — | — | 2 | |
| Vulvovaginitis | D014848 | EFO_1001240 | N76.0 | — | 2 | — | — | — | 2 |
| Leishmaniasis | D007896 | EFO_0005044 | B55 | 1 | 2 | — | — | — | 2 |
| Hematopoietic stem cell transplantation | D018380 | — | 1 | — | — | — | 1 | ||
| Fever | D005334 | HP_0001945 | R50.9 | — | 1 | — | — | — | 1 |
| Cryptococcosis | D003453 | EFO_0007229 | B45 | 1 | 1 | — | — | — | 1 |
| Hiv | D006678 | O98.7 | — | 1 | — | — | — | 1 | |
| Meningitis | D008581 | EFO_0000584 | G03 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 1 | — | — | — | — | 1 | ||
| Therapeutic equivalency | D013810 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Respiratory distress syndrome | D012128 | EFO_1000637 | J80 | — | — | — | — | 1 | 1 |
| Critical illness | D016638 | — | — | — | — | 1 | 1 | ||
| Ventilator-associated pneumonia | D053717 | EFO_1001865 | J95.851 | — | — | — | — | 1 | 1 |
| Respiratory tract infections | D012141 | J06.9 | — | — | — | — | 1 | 1 | |
| Pneumonia | D011014 | EFO_0003106 | J18 | — | — | — | — | 1 | 1 |
| Healthy diet | D000072001 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | AMPHOTERICIN B |
| INN | amphotericin b |
| Description | Amphotericin B is a macrolide antibiotic used to treat potentially life-threatening fungal infections. It has a role as an antiprotozoal drug, a bacterial metabolite and an antiamoebic agent. It is a macrolide antibiotic, a polyene antibiotic and an antibiotic antifungal drug. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | C[C@@H]1OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@]2(O)C[C@H](O)[C@@H](C(=O)O)[C@H](C[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@H]1C)O2 |
Identifiers
| PDB | — |
| CAS-ID | 1397-89-3 |
| RxCUI | 732 |
| ChEMBL ID | CHEMBL267345 |
| ChEBI ID | 2682 |
| PubChem CID | 5280965 |
| DrugBank | DB00681 |
| UNII ID | 7XU7A7DROE (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
Ambisome - Gilead Sciences
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Trends
PubMed Central
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Additional graphs summarizing 71,688 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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20,292 adverse events reported
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