Kineret(anakinra)
Kineret (anakinra) is a protein pharmaceutical. Anakinra was first approved as Kineret on 2001-11-14. It is used to treat cryopyrin-associated periodic syndromes and rheumatoid arthritis in the USA. It has been approved in Europe to treat rheumatoid arthritis.
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Commercial
Trade Name
FDA
EMA
Kineret
Drug Products
FDA
EMA
Reference product - 351(a)
Reference product - 351(a)
Interchangeable product - 351(k)
Interchangeable product - 351(k)
Biosimilar product - 351(k)
Biosimilar product - 351(k)
Anakinra
Tradename | Proper name | Company | Number | Date | Products |
|---|---|---|---|---|---|
| Kineret | anakinra | Swedish Orphan Biovitrum AB (publ) | N-103950 RX | 2001-11-14 | 1 products |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| kineret | Biologic Licensing Application | 2020-12-30 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| cryopyrin-associated periodic syndromes | — | D056587 | M04.2 |
| rheumatoid arthritis | EFO_0000685 | D001172 | M06.9 |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
anakinra, Kineret, Swedish Orphan Biovitrum AB (publ) | |||
| 2027-12-18 | Orphan excl. | ||
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
166 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | 3 | 1 | 3 | 4 | 11 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 3 | — | 1 | 3 | 7 |
| Knee injuries | D007718 | 1 | 1 | — | 1 | — | 2 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | U07.1 | — | 7 | 6 | — | 1 | 13 | |
| Heart failure | D006333 | EFO_0003144 | I50 | 2 | 7 | 2 | — | 1 | 8 |
| Cytokine release syndrome | D000080424 | D89.83 | — | 4 | 2 | — | — | 5 | |
| Mucocutaneous lymph node syndrome | D009080 | EFO_0004246 | M30.3 | 2 | 2 | 1 | — | — | 4 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | 2 | 4 | 1 | — | — | 4 |
| Pneumonia | D011014 | EFO_0003106 | J18 | — | 2 | 3 | — | — | 3 |
| Metabolic syndrome | D024821 | EFO_0000195 | E88.81 | — | 1 | 2 | — | — | 3 |
| Virus diseases | D014777 | B34 | — | 3 | 1 | — | — | 3 | |
| Juvenile arthritis | D001171 | EFO_0002609 | M08 | — | 1 | 1 | — | 1 | 3 |
| Chronic renal insufficiency | D051436 | N18 | — | 3 | 1 | — | — | 3 |
Show 19 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Inflammation | D007249 | 2 | 3 | — | — | 2 | 6 | ||
| Multiple myeloma | D009101 | C90.0 | 2 | 3 | — | — | — | 4 | |
| Macrophage activation syndrome | D055501 | EFO_1001806 | 1 | 3 | — | — | — | 4 | |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | — | 3 | — | — | 1 | 4 |
| B-cell lymphoma | D016393 | — | 3 | — | — | — | 3 | ||
| Asthma | D001249 | EFO_0000270 | J45 | 3 | 3 | — | — | — | 3 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 2 | 1 | — | — | — | 3 |
| Large b-cell lymphoma diffuse | D016403 | C83.3 | — | 2 | — | — | — | 2 | |
| Non-hodgkin lymphoma | D008228 | C85.9 | — | 2 | — | — | — | 2 | |
| Hypoglycemia | D007003 | HP_0001943 | E16.2 | — | 1 | — | — | 1 | 2 |
Show 36 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 3 | — | — | — | — | 3 | ||
| Neoplasms | D009369 | C80 | 2 | — | — | — | — | 2 | |
| Cryopyrin-associated periodic syndromes | D056587 | M04.2 | 1 | — | — | — | 1 | 2 | |
| Pain | D010146 | EFO_0003843 | R52 | 1 | — | — | — | 1 | 2 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | — | — | — | — | 1 |
| B-cell chronic lymphocytic leukemia | D015451 | C91.1 | 1 | — | — | — | — | 1 | |
| Castration-resistant prostatic neoplasms | D064129 | 1 | — | — | — | — | 1 | ||
| Chronic granulomatous disease | D006105 | EFO_0000338 | D71 | 1 | — | — | — | — | 1 |
| Endometriosis | D004715 | EFO_0001065 | N80 | 1 | — | — | — | — | 1 |
| Pulmonary arterial hypertension | D000081029 | 1 | — | — | — | — | 1 |
Show 6 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bariatric surgery | D050110 | — | — | — | — | 1 | 1 | ||
| Dumping syndrome | D004377 | EFO_1001307 | K91.1 | — | — | — | — | 1 | 1 |
| Adiposity | D050154 | — | — | — | — | 1 | 1 | ||
| Gestational diabetes | D016640 | HP_0009800 | O24.4 | — | — | — | — | 1 | 1 |
| Coronary artery disease | D003324 | I25.1 | — | — | — | — | 1 | 1 | |
| Glucose intolerance | D018149 | HP_0000833 | R73.03 | — | — | — | — | 1 | 1 |
| Respiratory insufficiency | D012131 | HP_0002093 | J96.9 | — | — | — | — | 1 | 1 |
| Conversion disorder | D003291 | F44 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | ANAKINRA |
| INN | anakinra |
| Description | Interleukin-1 receptor antagonist protein precursor (IL-1ra) (IRAP) |
| Classification | Protein |
| Drug class | interleukin receptor antagonists: interleukin-1 (IL-1) receptor antagonists |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | 143090-92-0 |
| RxCUI | 72435 |
| ChEMBL ID | CHEMBL1201570 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB00026 |
| UNII ID | 9013DUQ28K (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 13,573 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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6,914 adverse events reported
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