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Anisindione
Miradon (anisindione) is a small molecule pharmaceutical. Anisindione was first approved as Miradon on 1982-01-01. It is used to treat atrial fibrillation, coronary occlusion, embolism, myocardial infarction, and pulmonary embolism amongst others in the USA. The pharmaceutical is active against vitamin K-dependent gamma-carboxylase.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
respiratory tract diseasesD012140
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Anisindione
Tradename
Company
Number
Date
Products
MIRADONMerck Sharp & DohmeN-010909 DISCN1982-01-01
1 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
atrial fibrillationEFO_0000275D001281I48.0
coronary occlusion—D054059I21
embolism—D004617—
myocardial infarctionEFO_0000612D009203I21
pulmonary embolismEFO_0003827D011655I26
thromboembolismHP_0001907D013923—
venous thrombosisHP_0004936D020246I82.40
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameANISINDIONE
INNanisindione
Description
Anisindione is a cyclic beta-diketone consisting of indane-1,3-dione having a 4-methoxyphenyl substituent at the 4-position. It has a role as an anticoagulant and a vitamin K antagonist. It is a beta-diketone and an aromatic ketone. It derives from a hydride of an indane.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
COc1ccc(C2C(=O)c3ccccc3C2=O)cc1
Identifiers
PDB—
CAS-ID117-37-3
RxCUI17941
ChEMBL IDCHEMBL712
ChEBI ID133809
PubChem CID2197
DrugBankDB01125
UNII IDS747T1ERAJ (ChemIDplus, GSRS)
Target
Agency Approved
GGCX
GGCX
Organism
Homo sapiens
Gene name
GGCX
Gene synonyms
GC
NCBI Gene ID
2677
Protein name
vitamin K-dependent gamma-carboxylase
Protein synonyms
Gamma-glutamyl carboxylase, Peptidyl-glutamate 4-carboxylase, Vitamin K gamma glutamyl carboxylase
Uniprot ID
Q6GU45
Mouse ortholog
Ggcx (56316)
vitamin K-dependent gamma-carboxylase (Q9QYC7)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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289 adverse events reported
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