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Apokyn, Uprima(apomorphine)
Apokyn, Ixense, Kynmobi, Taluvian, Uprima (apomorphine) is a small molecule pharmaceutical. Apomorphine was first approved as Uprima on 2001-05-28. It is used to treat parkinson disease in the USA. It has been approved in Europe to treat erectile dysfunction. The pharmaceutical is active against D(2) dopamine receptor, D(3) dopamine receptor, and D(4) dopamine receptor. In addition, it is known to target 5-hydroxytryptamine receptor 2C, alpha-2A adrenergic receptor, D(1A) dopamine receptor, alpha-2C adrenergic receptor, D(1B) dopamine receptor, alpha-2B adrenergic receptor, 5-hydroxytryptamine receptor 2B, 5-hydroxytryptamine receptor 1A, 5-hydroxytryptamine receptor 2A, and transient receptor potential cation channel subfamily A member 1.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
urogenital diseasesD000091642
mental disordersD001523
Trade Name
FDA
EMA
Apokyn, Kynmobi (generic drugs available since 2022-02-23)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Apomorphine hydrochloride
Tradename
Company
Number
Date
Products
APOKYNMDD US OperationsN-021264 RX2004-04-20
1 products, RLD, RS
KYNMOBISunovion PharmaceuticalsN-210875 RX2020-05-21
5 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
apokynNew Drug Application2020-12-17
kynmobiNew Drug Application2020-06-26
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
parkinson diseaseEFO_0002508D010300G20
Agency Specific
FDA
EMA
Expiration
Code
APOMORPHINE HYDROCHLORIDE, KYNMOBI, SUNOVION PHARMS INC
2023-05-21NP
Patent Expiration
Patent
Expires
Flag
FDA Information
Apomorphine Hydrochloride, Kynmobi, Sunovion Pharms Inc
104491462036-04-19U-2825
109599432036-04-19U-2825
84149222031-12-16DPU-2825
88460742031-12-16DPU-2825
114197692031-12-16DPU-2825
90444752030-06-11DP
92832192030-06-11DPU-2825
93269812030-06-11U-2825
96690192030-06-11DPU-2825
96690212030-06-11U-2825
104207632030-06-11DPU-2825
108210742029-08-07DP
86035142024-04-03DP
87651672024-02-20DP
86636872023-02-02DP
ATC Codes
G: Genito urinary system and sex hormones
— G04: Urologicals
— G04B: Urologicals
— G04BE: Drugs used in erectile dysfunction
— G04BE07: Apomorphine
N: Nervous system drugs
— N04: Anti-parkinson drugs
— N04B: Dopaminergic agents
— N04BC: Dopamine agonists
— N04BC07: Apomorphine
HCPCS
Code
Description
J0364
Injection, apomorphine hydrochloride, 1 mg
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameAPOMORPHINE
INN—
Description
Apomorphine is an aporphine alkaloid. It has a role as an alpha-adrenergic drug, a serotonergic drug, an antidyskinesia agent, a dopamine agonist, an antiparkinson drug and an emetic. It derives from a hydride of an aporphine.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3
Identifiers
PDB—
CAS-ID58-00-4
RxCUI1043
ChEMBL IDCHEMBL53
ChEBI ID48538
PubChem CID6005
DrugBankDB00714
UNII ID—
Target
Agency Approved
DRD2
DRD2
DRD3
DRD3
DRD4
DRD4
Organism
Homo sapiens
Gene name
DRD2
Gene synonyms
NCBI Gene ID
1813
Protein name
D(2) dopamine receptor
Protein synonyms
Dopamine D2 receptor, seven transmembrane helix receptor
Uniprot ID
Q9UPA9
Mouse ortholog
Drd2 (13489)
D(2) dopamine receptor (Q0VGH9)
Alternate
HTR2C
HTR2C
ADRA2A
ADRA2A
DRD1
DRD1
ADRA2C
ADRA2C
DRD5
DRD5
ADRA2B
ADRA2B
HTR2B
HTR2B
HTR1A
HTR1A
HTR2A
HTR2A
TRPA1
TRPA1
Organism
Homo sapiens
Gene name
HTR2C
Gene synonyms
HTR1C
NCBI Gene ID
3358
Protein name
5-hydroxytryptamine receptor 2C
Protein synonyms
5-HT-1C, 5-HT1C, 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled, 5-hydroxytryptamine receptor 1C, serotonin 5-HT-1C receptor, serotonin 5-HT-2C receptor, Serotonin receptor 2C
Uniprot ID
Q9NP28
Mouse ortholog
Htr2c (15560)
5-hydroxytryptamine receptor 2C (Q5WRU6)
Variants
Clinical Variant
No data
Financial
Apokyn - Supernus Pharmaceuticals
$
€
£
₣
Mock data
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 9,918 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1 adverse events reported
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