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Apratastat
Apratastat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target disintegrin and metalloproteinase domain-containing protein 17, collagenase 3, and interstitial collagenase.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
1 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Rheumatoid arthritisD001172EFO_0000685M06.9—1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameAPRATASTAT
INNapratastat
Description
Apratastat is a sulfonamide.
Classification
Small molecule
Drug classenzyme inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC1(C)SCCN(S(=O)(=O)c2ccc(OCC#CCO)cc2)[C@H]1C(=O)NO
Identifiers
PDB—
CAS-ID287405-51-0
RxCUI—
ChEMBL IDCHEMBL206815
ChEBI ID—
PubChem CID—
DrugBankDB13020
UNII IDC6BZ5263BJ (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
ADAM17
ADAM17
MMP13
MMP13
MMP1
MMP1
Organism
Homo sapiens
Gene name
ADAM17
Gene synonyms
CSVP, TACE
NCBI Gene ID
6868
Protein name
disintegrin and metalloproteinase domain-containing protein 17
Protein synonyms
a disintegrin and metalloproteinase 17, ADAM metallopeptidase domain 18, cartilage snake venom-like protease, CD156b, Snake venom-like protease, TNF-alpha convertase, TNF-alpha convertase enzyme, TNF-alpha converting enzyme, TNF-alpha-converting enzyme, tumor necrosis factor, alpha, converting enzyme
Uniprot ID
P78536
Mouse ortholog
Adam17 (11491)
disintegrin and metalloproteinase domain-containing protein 17 (Q9Z0F8)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 42 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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