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Atabecestat
Atabecestat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target beta-secretase 1 and beta-secretase 2.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
15 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Asymptomatic diseasesD058070—11——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Alzheimer diseaseD000544EFO_0000249F0332———5
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—9————9
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameATABECESTAT
INNatabecestat
Description
Atabecestat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target beta-secretase 1 and beta-secretase 2.
Classification
Small molecule
Drug classenzyme inhibitors: beta secretase inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
C[C@@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)C=CSC(N)=N1
Identifiers
PDB—
CAS-ID1200493-78-2
RxCUI—
ChEMBL IDCHEMBL3916243
ChEBI ID—
PubChem CID—
DrugBank—
UNII ID2834W8D6GK (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
BACE1
BACE1
BACE2
BACE2
Organism
Homo sapiens
Gene name
BACE1
Gene synonyms
BACE, KIAA1149
NCBI Gene ID
23621
Protein name
beta-secretase 1
Protein synonyms
APP beta-secretase, Asp 2, ASP2, Aspartyl protease 2, beta-site amyloid beta A4 precursor protein-cleaving enzyme, Beta-site amyloid precursor protein cleaving enzyme 1, Beta-site APP cleaving enzyme 1, beta-site APP-cleaving enzyme, Memapsin-2, Membrane-associated aspartic protease 2, transmembrane aspartic proteinase Asp2
Uniprot ID
P56817
Mouse ortholog
Bace1 (23821)
beta-secretase 1 (P56818)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 159 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1 adverse events reported
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