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Atopaxar
Atopaxar is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target proteinase-activated receptor 1.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
6 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Acute coronary syndromeD054058EFO_0005672—2———2
Coronary artery diseaseD003324I25.1—2———2
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—2————2
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameATOPAXAR
INNatopaxar
Description
Atopaxar is an aromatic ketone.
Classification
Small molecule
Drug classProtease-activated receptor 1 (PAR1) antagonists
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCOc1cc2c(c(F)c1OCC)C(=N)N(CC(=O)c1cc(N3CCOCC3)c(OC)c(C(C)(C)C)c1)C2
Identifiers
PDB—
CAS-ID751475-53-3
RxCUI—
ChEMBL IDCHEMBL2103856
ChEBI ID—
PubChem CID—
DrugBankDB12046
UNII IDHTI275SD2D (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
F2R
F2R
Organism
Homo sapiens
Gene name
F2R
Gene synonyms
CF2R, PAR1, TR
NCBI Gene ID
2149
Protein name
proteinase-activated receptor 1
Protein synonyms
Coagulation factor II receptor, protease-activated receptor 1, Thrombin receptor
Uniprot ID
P25116
Mouse ortholog
F2r (14062)
proteinase-activated receptor 1 (Q3TVP3)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 110 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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