Atracurium
Tracrium (atracurium) is a small molecule pharmaceutical. Atracurium was first approved as Tracrium preservative free on 1983-11-23. It is known to target neuronal acetylcholine receptor subunit alpha-4, neuronal acetylcholine receptor subunit alpha-7, acetylcholine receptor subunit alpha, and neuronal acetylcholine receptor subunit alpha-3.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| atracurium besylate | ANDA | 2022-11-01 |
Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
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Clinical
Clinical Trials
177 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Attention deficit disorder with hyperactivity | D001289 | EFO_0003888 | F90 | 2 | 14 | 27 | 42 | 13 | 97 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | 1 | 3 | 1 | 2 | 1 | 7 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | 1 | 1 | — | 2 | 1 | 5 |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | — | 2 | — | 2 | 1 | 5 |
| Marijuana abuse | D002189 | EFO_0007191 | F12 | — | 3 | — | 1 | — | 4 |
| Orthostatic hypotension | D007024 | I95.1 | 1 | 1 | — | 1 | — | 3 | |
| Dyslexia | D004410 | EFO_0005424 | F81.0 | — | — | — | 3 | — | 3 |
| Autistic disorder | D001321 | EFO_0003758 | F84.0 | — | — | 1 | 2 | — | 3 |
| Attention deficit and disruptive behavior disorders | D019958 | HP_0010865 | F91.3 | — | — | 2 | 1 | — | 3 |
| Depression | D003863 | F33.9 | — | — | — | 1 | 1 | 2 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Obstructive sleep apnea | D020181 | EFO_0003918 | G47.33 | 5 | 10 | — | — | — | 10 |
| Cocaine-related disorders | D019970 | F14 | 2 | 1 | — | — | 1 | 4 | |
| Opioid-related disorders | D009293 | EFO_0005611 | F11 | — | 1 | — | — | 1 | 2 |
| Orthostatic intolerance | D054971 | 2 | 1 | — | — | — | 2 | ||
| Memory disorders | D008569 | — | 2 | — | — | — | 2 | ||
| Cognitive dysfunction | D060825 | G31.84 | — | 2 | — | — | — | 2 | |
| Tachycardia | D013610 | HP_0001649 | R00.0 | 1 | 1 | — | — | — | 1 |
| Down syndrome | D004314 | EFO_0001064 | Q90 | — | 1 | — | — | — | 1 |
| Sleep apnea syndromes | D012891 | EFO_0003877 | G47.3 | — | 1 | — | — | — | 1 |
| Physiological stress | D013312 | 1 | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pure autonomic failure | D054970 | 1 | — | — | — | 1 | 2 | ||
| Healthy volunteers/patients | — | 1 | — | — | — | — | 1 | ||
| Alcohol-induced disorders | D020751 | 1 | — | — | — | — | 1 | ||
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Anorexia nervosa | D000856 | EFO_0004215 | F50.0 | — | — | — | — | 1 | 1 |
| Multiple system atrophy | D019578 | — | — | — | — | 1 | 1 | ||
| Parkinsonian disorders | D020734 | HP_0001300 | — | — | — | — | 1 | 1 | |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | — | — | 1 | 1 |
| Transient ischemic attack | D002546 | EFO_0003764 | G45.9 | — | — | — | — | 1 | 1 |
| Menopause | D008593 | EFO_0003922 | N95 | — | — | — | — | 1 | 1 |
| Whiplash injuries | D014911 | — | — | — | — | 1 | 1 | ||
| Neurofeedback | D058765 | — | — | — | — | 1 | 1 | ||
| Morbid obesity | D009767 | EFO_0001074 | — | — | — | — | 1 | 1 | |
| Traumatic brain injuries | D000070642 | S06 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | ATRACURIUM |
| INN | atracurium besilate |
| Description | Atracurium besylate is the bisbenzenesulfonate salt of atracurium. It has a role as a nicotinic antagonist and a muscle relaxant. It is a quaternary ammonium salt and an organosulfonate salt. It contains an atracurium. |
| Classification | Small molecule |
| Drug class | quaternary ammonium derivatives: neuromuscular blocking agents |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | COc1ccc(CC2c3cc(OC)c(OC)cc3CC[N+]2(C)CCC(=O)OCCCCCOC(=O)CC[N+]2(C)CCc3cc(OC)c(OC)cc3C2Cc2ccc(OC)c(OC)c2)cc1OC |
Identifiers
| PDB | — |
| CAS-ID | 64228-79-1 |
| RxCUI | 1219 |
| ChEMBL ID | CHEMBL1360 |
| ChEBI ID | 2914 |
| PubChem CID | 47320 |
| DrugBank | DB00732 |
| UNII ID | 40AX66P76P (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
CHRNA4
CHRNA4
CHRNA7
CHRNA7
CHRNA1
CHRNA1
CHRNA3
CHRNA3
Organism
Homo sapiens
Gene name
CHRNA4
Gene synonyms
NACRA4
NCBI Gene ID
Protein name
neuronal acetylcholine receptor subunit alpha-4
Protein synonyms
cholinergic receptor, nicotinic alpha 4, cholinergic receptor, nicotinic, alpha 4 (neuronal), cholinergic receptor, nicotinic, alpha polypeptide 4, neuronal nicotinic acetylcholine receptor alpha-4 subunit
Uniprot ID
Mouse ortholog
Chrna4 (11438)
neuronal acetylcholine receptor subunit alpha-4 (Q9ET51)
Variants
Clinical Variant
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Financial
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Trends
PubMed Central
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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20,078 adverse events reported
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