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Atrasentan
Atrasentan is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against endothelin-1 receptor. In addition, it is known to target endothelin receptor type B.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
20 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Prostatic neoplasmsD011471C61—35——7
Diabetic nephropathiesD003928EFO_0000401—51——6
Iga glomerulonephritisD005922EFO_0004194—11——2
NeoplasmsD009369C80——1——1
AdenocarcinomaD000230—11——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Chronic renal insufficiencyD051436N18—4———4
Ovarian neoplasmsD010051EFO_0003893C56—1———1
Fallopian tube neoplasmsD005185—1———1
Focal segmental glomerulosclerosisD005923EFO_0004236—1———1
Hereditary nephritisD009394EFO_0004128Q87.81—1———1
Kidney neoplasmsD007680EFO_0003865C64—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Central nervous system neoplasmsD0165431————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameATRASENTAN
INNatrasentan
Description
Atrasentan is a member of pyrrolidines.
Classification
Small molecule
Drug classendothelin receptor antagonists
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1
Identifiers
PDB—
CAS-ID173937-91-2
RxCUI282355
ChEMBL IDCHEMBL9194
ChEBI ID—
PubChem CID159594
DrugBankDB06199
UNII IDV6D7VK2215 (ChemIDplus, GSRS)
Target
Agency Approved
EDNRA
EDNRA
Organism
Homo sapiens
Gene name
EDNRA
Gene synonyms
ETA, ETRA
NCBI Gene ID
1909
Protein name
endothelin-1 receptor
Protein synonyms
endothelin receptor subtype A, Endothelin receptor type A, endothelin-1-specific receptor, ET-A, ETA-R, G protein-coupled receptor, hET-AR
Uniprot ID
P25101
Mouse ortholog
Ednra (13617)
endothelin-1 receptor (Q91VV2)
Alternate
EDNRB
EDNRB
Organism
Homo sapiens
Gene name
EDNRB
Gene synonyms
ETRB
NCBI Gene ID
1910
Protein name
endothelin receptor type B
Protein synonyms
Endothelin receptor non-selective type, endothelin receptor subtype B1, Hirschsprung disease 2
Uniprot ID
Q9UQK3
Mouse ortholog
Ednrb (13618)
endothelin receptor type B (Q542M3)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,193 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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165 adverse events reported
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