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Avadomide
Avadomide is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target protein cereblon.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
15 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Non-hodgkin lymphomaD008228C85.941———4
Large b-cell lymphoma diffuseD016403C83.341———4
Liver neoplasmsD008113EFO_1001513C22.021———2
Follicular lymphomaD008224C8211———1
B-cell chronic lymphocytic leukemiaD015451C91.111———1
MelanomaD008545—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—2————2
Multiple myelomaD009101C90.01————1
GlioblastomaD005909EFO_00005151————1
LymphomaD008223C85.91————1
Renal insufficiencyD051437HP_0000083N191————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameAVADOMIDE
INNavadomide
Description
Avadomide is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target protein cereblon.
Classification
Small molecule
Drug classthalidomide derivatives
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Cc1nc2cccc(N)c2c(=O)n1C1CCC(=O)NC1=O
Identifiers
PDB—
CAS-ID1015474-32-4
RxCUI—
ChEMBL IDCHEMBL3989934
ChEBI ID—
PubChem CID—
DrugBank—
UNII ID28DZS29F59 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
CRBN
CRBN
Organism
Homo sapiens
Gene name
CRBN
Gene synonyms
NCBI Gene ID
51185
Protein name
protein cereblon
Protein synonyms
protein x 0001
Uniprot ID
Q96SW2
Mouse ortholog
Crbn (58799)
protein cereblon (Q8C7D2)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 121 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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38 adverse events reported
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