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Avoralstat
Avoralstat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target plasma kallikrein.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
5 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hereditary angioedemasD054179EFO_0004131222——5
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameAVORALSTAT
INNavoralstat
Description
Avoralstat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target plasma kallikrein.
Classification
Small molecule
Drug classenzyme inhibitors: 1) kallikrein inhibitors or 2) serine protease inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
C=Cc1cc(C(=O)Nc2ccc(C(=N)N)cc2)c(-c2ccc(C(=O)NCC3CC3)nc2C(=O)O)cc1OC
Identifiers
PDB—
CAS-ID918407-35-9
RxCUI—
ChEMBL IDCHEMBL4297502
ChEBI ID—
PubChem CID—
DrugBank—
UNII IDUX17773O15 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
KLKB1
KLKB1
Organism
Homo sapiens
Gene name
KLKB1
Gene synonyms
KLK3
NCBI Gene ID
3818
Protein name
plasma kallikrein
Protein synonyms
Fletcher factor, kallikrein B, plasma (Fletcher factor) 1, Kininogenin, PKK, Plasma prekallikrein
Uniprot ID
P03952
Mouse ortholog
Klkb1 (16621)
plasma kallikrein (Q8R0P5)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 42 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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