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Azactam, Cayston(aztreonam)
Azactam, Cayston (aztreonam) is a small molecule pharmaceutical. Aztreonam was first approved as Azactam on 1986-12-31. It is used to treat bacterial infections, cellulitis, endometritis, intraabdominal infections, and pseudomonas infections amongst others in the USA. It has been approved in Europe to treat cystic fibrosis and respiratory tract infections.
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BMS
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
digestive system diseasesD004066
respiratory tract diseasesD012140
urogenital diseasesD000091642
hereditary congenital and neonatal diseases and abnormalitiesD009358
skin and connective tissue diseasesD017437
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Azactam, Cayston (generic drugs available since 2010-06-18)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Aztreonam
Tradename
Company
Number
Date
Products
AZACTAMBristol Myers SquibbN-050580 RX1986-12-31
2 products, RLD, RS
CAYSTONGilead SciencesN-050814 RX2010-02-22
1 products, RLD, RS
Show 2 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
azactamNew Drug Application2021-03-11
caystonNew Drug Application2019-11-25
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
bacterial infections—D001424A49
cellulitisEFO_0003035D002481L03.90
endometritisEFO_1001312D004716—
intraabdominal infections—D059413—
pseudomonas infectionsEFO_0001076D011552—
respiratory tract infections—D012141J06.9
urinary tract infectionsEFO_0003103D014552N39.0
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
J: Antiinfectives for systemic use
— J01: Antibacterials for systemic use
— J01D: Other beta-lactam antibacterials in atc
— J01DF: Monobactams
— J01DF01: Aztreonam
HCPCS
Code
Description
S0073
Injection, aztreonam, 500 mg
Clinical
Clinical Trials
35 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Cystic fibrosisD003550EFO_0000390E84—31149
InfectionsD007239EFO_00005441112—4
PseudomonasD011549———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Bacterial infectionsD001424A49224——7
Soft tissue infectionsD018461——3——3
Infectious skin diseasesD012874——2——2
GonorrheaD006069DOID_7551A54—11——1
Ventilator-associated pneumoniaD053717EFO_1001865J95.851—11——1
Respiratory tract infectionsD012141J06.9—11——1
Bacterial skin diseasesD017192——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Pseudomonas aeruginosaD011550NCBITaxon_287—1——12
BronchiectasisD001987HP_0002110J47—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—2————2
Renal insufficiencyD051437HP_0000083N191————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Pseudomonas infectionsD011552EFO_0001076————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameAZTREONAM
INNaztreonam
Description
Aztreonam, sold under the brand name Azactam among others, is an antibiotic used primarily to treat infections caused by gram-negative bacteria such as Pseudomonas aeruginosa. This may include bone infections, endometritis, intra abdominal infections, pneumonia, urinary tract infections, and sepsis. It is given by intravenous or intramuscular injection or by inhalation.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
C[C@H]1[C@H](NC(=O)/C(=N\OC(C)(C)C(=O)O)c2csc(N)n2)C(=O)N1S(=O)(=O)O
Identifiers
PDB—
CAS-ID78110-38-0
RxCUI1272
ChEMBL IDCHEMBL158
ChEBI ID161680
PubChem CID5742832
DrugBankDB00355
UNII IDG2B4VE5GH8 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
Azactam - Elan Corporation
$
€
£
₣
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 13,655 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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28,935 adverse events reported
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