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Bardoxolone
Bardoxolone is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target peroxisome proliferator-activated receptor gamma and kelch-like ECH-associated protein 1.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
28 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Chronic renal insufficiencyD051436N18342——9
Type 2 diabetes mellitusD003924EFO_0001360E11341——8
Diabetic nephropathiesD003928EFO_0000401—21——3
Autosomal dominant polycystic kidneyD016891EFO_1001496Q61.2—12——3
Pulmonary hypertensionD006976EFO_0001361I27.20—11——2
Hereditary nephritisD009394EFO_0004128Q87.81—12——2
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
SarcoidosisD012507EFO_0000690D80-D89—1———1
Pulmonary arterial hypertensionD000081029—1———1
Idiopathic pulmonary fibrosisD054990J84.112—1———1
Interstitial lung diseasesD017563EFO_0004244J84.89—1———1
Cryptogenic organizing pneumoniaD018549EFO_1001300J84.116—1———1
Idiopathic interstitial pneumoniasD054988—1———1
Hamman-rich syndromeD000080203J84.11—1———1
Covid-19D000086382U07.1—1———1
Iga glomerulonephritisD005922EFO_0004194—1———1
Type 1 diabetes mellitusD003922EFO_0001359E10—1———1
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—5————5
Hepatic insufficiencyD0485501————1
NeoplasmsD009369C801————1
Pancreatic neoplasmsD010190EFO_0003860C251————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameBARDOXOLONE
INNbardoxolone
Description
Bardoxolone methyl is a member of cyclohexenones.
Classification
Small molecule
Drug classsteroids (not prednisolone derivatives)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC1(C)CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](C(=O)C=C4[C@@]3(C)CC[C@H]3C(C)(C)C(=O)C(C#N)=C[C@]43C)[C@@H]2C1
Identifiers
PDB—
CAS-ID218600-44-3
RxCUI—
ChEMBL IDCHEMBL1093059
ChEBI ID—
PubChem CID400769
DrugBankDB12651
UNII ID7HT68L8941 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
PPARG
PPARG
KEAP1
KEAP1
Organism
Homo sapiens
Gene name
PPARG
Gene synonyms
NR1C3
NCBI Gene ID
5468
Protein name
peroxisome proliferator-activated receptor gamma
Protein synonyms
Nuclear receptor subfamily 1 group C member 3, peroxisome proliferator-activated receptor-gamma 5, peroxisome proliferator-activated receptor-gamma splicing, PPAR-gamma
Uniprot ID
Q96J12
Mouse ortholog
Pparg (19016)
peroxisome proliferator-activated receptor gamma (P37238)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,628 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1 adverse events reported
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