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Belvarafenib
Belvarafenib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target RAF proto-oncogene serine/threonine-protein kinase and serine/threonine-protein kinase B-raf.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
2 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369C80—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
MelanomaD0085451————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameBELVARAFENIB
INNbelvarafenib
Description
Belvarafenib (developed by Hanmi Pharmaceuticals and Genentech) is a small molecule RAF dimer (type II) inhibitor which shows anti-tumor clinical activity in cancer patients with BRAFV600E- and NRAS- mutations.
Classification
Small molecule
Drug classrapidly accelerated fibrosarcoma (RAF) kinase inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Cc1ccc2c(Nc3cccc(Cl)c3F)nccc2c1NC(=O)c1csc2c(N)ncnc12
Identifiers
PDB—
CAS-ID1446113-23-0
RxCUI—
ChEMBL IDCHEMBL3977543
ChEBI ID—
PubChem CID89655386
DrugBank—
UNII ID31M3WLJ3KG (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
RAF1
RAF1
BRAF
BRAF
Organism
Homo sapiens
Gene name
RAF1
Gene synonyms
RAF
NCBI Gene ID
5894
Protein name
RAF proto-oncogene serine/threonine-protein kinase
Protein synonyms
C-Raf proto-oncogene, serine/threonine kinase, cRaf, Oncogene RAF1, Proto-oncogene c-RAF, raf proto-oncogene serine/threonine protein kinase, Raf-1, v-raf-1 murine leukemia viral oncogene homolog 1, v-raf-1 murine leukemia viral oncogene-like protein 1
Uniprot ID
Q9UC20
Mouse ortholog
Raf1 (110157)
RAF proto-oncogene serine/threonine-protein kinase (Q9QUU8)
Variants
Clinical Variant
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Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 65 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1 adverse events reported
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