Benzhydrocodone
Apadaz (benzhydrocodone) is a small molecule pharmaceutical. Benzhydrocodone was first approved as Apadaz on 2018-02-23. It is used to treat pain in the USA.
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Commercial
Trade Name
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EMA
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Acetaminophen
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Benzhydrocodone hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| APADAZ | KVK Tech | N-208653 DISCN | 2018-02-23 | 3 products, RLD |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| apadaz | New Drug Application | 2021-03-12 |
| benzhydrocodone and acetaminophen | NDA authorized generic | 2021-03-17 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| pain | EFO_0003843 | D010146 | R52 |
Agency Specific
FDA
EMA
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ATC Codes
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HCPCS
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Clinical
Clinical Trials
6 clinical trials
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Conscious sedation | D016292 | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Refractive errors | D012030 | EFO_0003908 | H52.7 | — | — | — | — | 1 | 1 |
| Blepharitis | D001762 | EFO_0009536 | H01.0 | — | — | — | — | 1 | 1 |
| Lacrimal apparatus diseases | D007766 | HP_0009926 | H04 | — | — | — | — | 1 | 1 |
| Corneal diseases | D003316 | H18.9 | — | — | — | — | 1 | 1 | |
| Microbiota | D064307 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | BENZHYDROCODONE |
| INN | benzhydrocodone |
| Description | Benzhydrocodone (INN) (contracted from benzoate-hydrocodone) is an opioid prodrug of the morphinan class. Its chemical structure consists of hydrocodone coupled with benzoic acid. Benzhydrocodone itself is inactive and acts as a prodrug to hydrocodone upon cleavage of the benzoate portion of the molecule.
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| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | COc1ccc2c3c1O[C@H]1C(OC(=O)c4ccccc4)=CC[C@@H]4[C@@H](C2)N(C)CC[C@@]341 |
Identifiers
| PDB | — |
| CAS-ID | 1259440-61-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3137321 |
| ChEBI ID | — |
| PubChem CID | 49836084 |
| DrugBank | DB15465 |
| UNII ID | 75MS0AAZ9I (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
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Variants
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Financial
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 26 documents
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Safety
Black-box Warning
Black-box warning for: Apadaz, Benzhydrocodone and acetaminophen
Adverse Events
Top Adverse Reactions
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117 adverse events reported
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