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Bepridil
Bepadin, Vascor (bepridil) is a small molecule pharmaceutical. Bepridil was first approved as Vascor on 1990-12-28. It is used to treat angina pectoris and hypertension in the USA. It is known to target potassium voltage-gated channel subfamily KQT member 4, potassium channel subfamily T member 1, and palmitoleoyl-protein carboxylesterase NOTUM.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Bepridil hydrochloride
Tradename
Company
Number
Date
Products
VASCORJohnson & JohnsonN-019002 DISCN1990-12-28
3 products
BEPADINMedpointe Pharm HlcN-019001 DISCN1990-12-28
3 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
angina pectorisEFO_0003913D000787I20
hypertensionEFO_0000537D006973I10
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C08: Calcium channel blockers
— C08E: Non-selective calcium channel blockers
— C08EA: Phenylalkylamine derivatives, non-selective calcium channel blockers
— C08EA02: Bepridil
HCPCS
No data
Clinical
Clinical Trials
8 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
SchizophreniaD012559EFO_0000692F20———112
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Back painD001416HP_0003418M54—2———2
SciaticaD012585HP_0011868M54.3—1———1
Hiv infectionsD015658EFO_0000764B20—1———1
Peripheral nervous system diseasesD010523G64—1———1
Temporomandibular joint disordersD013705M26.6—1———1
Cocaine-related disordersD019970F14—1———1
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Psychotic disordersD011618F20.81————11
Paranoid schizophreniaD012563F20.0————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameBEPRIDIL
INNbepridil
Description
Bepridil is a tertiary amine in which the substituents on nitrogen are benzyl, phenyl and 3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl. It has a role as a vasodilator agent, an anti-arrhythmia drug, an antihypertensive agent and a calcium channel blocker. It is a tertiary amine and a member of pyrrolidines.
Classification
Small molecule
Drug classvasodilators (undefined group)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1
Identifiers
PDB7BLI
CAS-ID64706-54-3
RxCUI1436
ChEMBL IDCHEMBL1008
ChEBI ID3061
PubChem CID2351
DrugBankDB01244
UNII ID755BO701MA (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
KCNQ4
KCNQ4
KCNT1
KCNT1
NOTUM
NOTUM
Organism
Homo sapiens
Gene name
KCNQ4
Gene synonyms
NCBI Gene ID
9132
Protein name
potassium voltage-gated channel subfamily KQT member 4
Protein synonyms
KQT-like 4, potassium channel KQT-like 4, Potassium channel subunit alpha KvLQT4, potassium channel, voltage gated KQT-like subfamily Q, member 4, potassium voltage-gated channel, KQT-like subfamily, member 4, Voltage-gated potassium channel subunit Kv7.4
Uniprot ID
P56696
Mouse ortholog
Kcnq4 (60613)
potassium voltage-gated channel subfamily KQT member 4 (Q9JK97)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,214 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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2,422 adverse events reported
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