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Brequinar
Brequinar is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target dihydroorotate dehydrogenase (quinone), mitochondrial.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
No data
ATC Codes
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HCPCS
No data
Clinical
Clinical Trials
4 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Covid-19D000086382U07.113———3
Myeloid leukemia acuteD015470C92.011———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameBREQUINAR
INNbrequinar
Description
Brequinar is a quinolinemonocarboxylic acid that is quinoline substituted by 2'-fluoro[1,1'-biphenyl]-4-yl, methyl, carboxy and fluoro groups at positions 2, 3, 4, and 6, respectively. It is an inhibitor of dihydroorotate dehydrogenase, an enzyme that is required for de novo pyrimidine biosynthesis. The compound exhibits antineoplastic and antiviral properties. It has a role as an EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor, an immunosuppressive agent, an antineoplastic agent, an antiviral agent, a pyrimidine synthesis inhibitor, an anticoronaviral agent and an antimetabolite. It is a member of biphenyls, a member of monofluorobenzenes, a quinolinemonocarboxylic acid and a monocarboxylic acid. It is a conjugate acid of a brequinar(1-).
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Cc1c(-c2ccc(-c3ccccc3F)cc2)nc2ccc(F)cc2c1C(=O)O
Identifiers
PDB—
CAS-ID96187-53-0
RxCUI—
ChEMBL IDCHEMBL38434
ChEBI ID—
PubChem CID57030
DrugBankDB03523
UNII ID5XL19F49H6 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
DHODH
DHODH
Organism
Homo sapiens
Gene name
DHODH
Gene synonyms
NCBI Gene ID
1723
Protein name
dihydroorotate dehydrogenase (quinone), mitochondrial
Protein synonyms
Dihydroorotate oxidase, human complement of yeast URA1
Uniprot ID
Q6P176
Mouse ortholog
Dhodh (56749)
dihydroorotate dehydrogenase (quinone), mitochondrial (O35435)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 576 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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27 adverse events reported
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