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Bretylium
Bretylol (bretylium) is a small molecule pharmaceutical. Bretylium was first approved as Bretylol on 1982-01-01. It is used to treat ventricular fibrillation and ventricular tachycardia in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Bretylium tosylate
Tradename
Company
Number
Date
Products
BRETYLIUM TOSYLATE IN DEXTROSE 5%Abbott BiotherapeuticsN-019005 DISCN1986-04-29
3 products
BRETYLIUM TOSYLATE IN DEXTROSE 5% IN PLASTIC CONTAINERB. Braun MedicalN-019121 DISCN1986-04-29
3 products
BRETYLIUM TOSYLATE IN DEXTROSE 5% IN PLASTIC CONTAINERBaxterN-019837 DISCN1989-04-12
2 products
BRETYLOLHospiraN-017954 DISCN1982-01-01
1 products
BRETYLIUM TOSYLATEHospiraN-019030 DISCN1986-04-29
1 products, RLD
BRETYLIUM TOSYLATEHospiraN-019033 DISCN1986-04-29
1 products
BRETYLIUM TOSYLATE IN DEXTROSE 5% IN PLASTIC CONTAINERHospiraN-019008 DISCN1986-04-29
3 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
ventricular fibrillationEFO_0004287D014693I49.01
ventricular tachycardia—D017180I47.2
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C01: Cardiac therapy drugs
— C01B: Antiarrhythmics, class i and iii
— C01BD: Antiarrhythmics, class iii
— C01BD02: Bretylium tosilate
HCPCS
No data
Clinical
Clinical Trials
151 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Head and neck neoplasmsD0062581231—7
NeoplasmsD009369C80——21—3
WartsD014860B07———1—1
KeloidD007627EFO_0004212L91.0———1—1
CicatrixD002921HP_0100699L90.5———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
LymphomaD008223C85.921918—240
Hodgkin diseaseD006689C8121216——29
Hiv infectionsD015658EFO_0000764B20425—112
Germ cell and embryonal neoplasmsD009373—35—210
Kaposi sarcomaD012514C46323——8
TeratomaD013724D28—34——6
Ovarian neoplasmsD010051EFO_0003893C56—13—15
Non-hodgkin lymphomaD008228C85.91—1—13
Large b-cell lymphoma diffuseD016403C83.3——2——2
CardiotoxicityD066126EFO_1001482——2——2
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Squamous cell carcinoma of head and neckD000077195—2———2
Central nervous system neoplasmsD016543—1——12
Vascular malformationsD054079—1——12
T-cell lymphoma peripheralD016411C84.9—1———1
Plasma cell neoplasmsD054219—1———1
PneumocephalusD011007EFO_1001398—1———1
Sex cord-gonadal stromal tumorsD018312EFO_1000052—1———1
Sertoli-leydig cell tumorD018310—1———1
Female genital neoplasmsD005833—1———1
Neoadjuvant therapyD020360—1———1
Show 4 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Pancreatic neoplasmsD010190EFO_0003860C252———13
Stomach neoplasmsD013274EFO_0003897C161————1
Brain neoplasmsD001932EFO_0003833C711————1
Skin neoplasmsD012878EFO_0004198C441————1
MelanomaD0085451————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Second primary neoplasmsD016609————11
HemangiomaD006391D18.0————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameBRETYLIUM
INNbretylium tosilate
Description
Bretylium is a quaternary ammonium cation having 2-bromobenzyl, ethyl and two methyl groups attached to the nitrogen. It blocks noradrenaline release from the peripheral sympathetic nervous system, and is used in emergency medicine, cardiology, and other specialties for the acute management of ventricular tachycardia and ventricular fibrillation. It has a role as an adrenergic antagonist, an anti-arrhythmia drug and an antihypertensive agent.
Classification
Small molecule
Drug classquaternary ammonium derivatives
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC[N+](C)(C)Cc1ccccc1Br
Identifiers
PDB—
CAS-ID59-41-6
RxCUI19685
ChEMBL IDCHEMBL1199080
ChEBI ID3172
PubChem CID2431
DrugBankDB01158
UNII ID78ZP3YR353 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,202 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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8,007 adverse events reported
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