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Brontictuzumab
Brontictuzumab is an antibody pharmaceutical. It is currently being investigated in clinical studies. It is known to target neurogenic locus notch homolog protein 1.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
4 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Colorectal neoplasmsD0151791————1
NeoplasmsD009369C801————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Adenoid cystic carcinomaD003528————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameBRONTICTUZUMAB
INNbrontictuzumab
Description
Brontictuzumab (INN; development code OMP-52M51) is a humanized monoclonal antibody designed for the treatment of cancer.
Classification
Antibody
Drug classmonoclonal antibodies
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)—
Identifiers
PDB—
CAS-ID1447814-75-6
RxCUI—
ChEMBL IDCHEMBL3545261
ChEBI ID—
PubChem CID—
DrugBankDB12737
UNII IDUNY2TQA40E (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
NOTCH1
NOTCH1
Organism
Homo sapiens
Gene name
NOTCH1
Gene synonyms
TAN1
NCBI Gene ID
4851
Protein name
neurogenic locus notch homolog protein 1
Protein synonyms
notch 1, Notch homolog 1, translocation-associated, Translocation-associated notch protein TAN-1
Uniprot ID
Q5SXM3
Mouse ortholog
Notch1 (18128)
neurogenic locus notch homolog protein 1 (Q9R0X7)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 71 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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