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Buclizine
Bucladin-s (buclizine) is a small molecule pharmaceutical. Buclizine was first approved as Bucladin-s on 1982-01-01. It is used to treat nausea, vertigo, and vomiting in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
otorhinolaryngologic diseasesD010038
nervous system diseasesD009422
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Buclizine hydrochloride
Tradename
Company
Number
Date
Products
BUCLADIN-SStuart PharmaceuticalsN-010911 DISCN1982-01-01
1 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
nauseaHP_0002018D009325R11.0
vertigo—D014717H81.39
vomitingHP_0002013D014839R11.1
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
R: Respiratory system drugs
— R06: Antihistamines for systemic use
— R06A: Antihistamines for systemic use
— R06AE: Piperazine derivatives, systemic antihistamines
— R06AE01: Buclizine
— R06AE51: Buclizine, combinations
HCPCS
No data
Clinical
Clinical Trials
3 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
InflammationD007249——2——2
RhinitisD012220EFO_0008521J31——2——2
CoughD003371HP_0012735R05——1——1
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypersensitivityD006967EFO_0003785T78.401————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameBUCLIZINE
INNbuclizine
Description
Buclizine is an N-alkylpiperazine carrying (4-chlorophenyl)(phenyl)methyl and 4-tert-butylbenzyl groups. It has a role as an antiemetic, a cholinergic antagonist, a histamine antagonist, a local anaesthetic and a central nervous system depressant. It is a N-alkylpiperazine and a member of monochlorobenzenes. It is a conjugate base of a buclizine(2+).
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(C)(C)c1ccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)cc1
Identifiers
PDB—
CAS-ID82-95-1
RxCUI59636
ChEMBL IDCHEMBL1201271
ChEBI ID3205
PubChem CID6729
DrugBankDB00354
UNII ID0C94V6X681 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 84 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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310 adverse events reported
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