Skip to content
Buspirone
Buspar (buspirone) is a small molecule pharmaceutical. Buspirone was first approved as Buspar on 1986-09-29. It is used to treat anxiety disorders, depressive disorder, and intellectual disability in the USA. The pharmaceutical is active against 5-hydroxytryptamine receptor 1A. In addition, it is known to target 5-hydroxytryptamine receptor 7.
Download report
Favorite
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
signs and symptoms pathological conditionsD013568
behavior and behavior mechanismsD001520
mental disordersD001523
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Buspirone hydrochloride
Tradename
Company
Number
Date
Products
BUSPARBristol Myers SquibbN-018731 DISCN1986-09-29
4 products, RLD
BUSPARBristol Myers SquibbN-021190 DISCN2000-12-20
4 products, RLD
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
busparANDA2016-05-25
buspirone hydrochlorideANDA2023-06-07
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
anxiety disordersEFO_0006788D001008F41.1
depressive disorderEFO_1002014D003866F32.A
intellectual disabilityHP_0001249D008607F73
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N05: Psycholeptics
— N05B: Anxiolytics
— N05BE: Azaspirodecanedione derivatives, anxiolytics
— N05BE01: Buspirone
HCPCS
No data
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
Drug common nameBUSPIRONE
INNbuspirone
Description
Buspirone is an azaspiro compound that is 8-azaspiro[4.5]decane-7,9-dione substituted at the nitrogen atom by a 4-(piperazin-1-yl)butyl group which in turn is substituted by a pyrimidin-2-yl group at the N(4) position. It has a role as an anxiolytic drug, a sedative, a serotonergic agonist and an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor. It is an azaspiro compound, a member of pyrimidines, a N-arylpiperazine, a N-alkylpiperazine, a member of piperidones and an organic heteropolycyclic compound. It is a conjugate base of a buspirone(1+).
Classification
Small molecule
Drug classanxiolytics (buspirone type)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(c2ncccn2)CC1
Identifiers
PDB—
CAS-ID36505-84-7
RxCUI1827
ChEMBL IDCHEMBL49
ChEBI ID3223
PubChem CID2477
DrugBankDB00490
UNII IDTK65WKS8HL (ChemIDplus, GSRS)
Target
Agency Approved
HTR1A
HTR1A
Organism
Homo sapiens
Gene name
HTR1A
Gene synonyms
ADRB2RL1, ADRBRL1
NCBI Gene ID
3350
Protein name
5-hydroxytryptamine receptor 1A
Protein synonyms
5-HT1a receptor, 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled, G-21, guanine nucleotide-binding regulatory protein-coupled receptor, Serotonin receptor 1A
Uniprot ID
Q6LAE7
Mouse ortholog
Htr1a (15550)
5-hydroxytryptamine receptor 1A (Q8BGS4)
Alternate
HTR7
HTR7
Organism
Homo sapiens
Gene name
HTR7
Gene synonyms
NCBI Gene ID
3363
Protein name
5-hydroxytryptamine receptor 7
Protein synonyms
5-HT-7, 5-HT-X, 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled), Serotonin receptor 7
Uniprot ID
P34969
Mouse ortholog
Htr7 (15566)
5-hydroxytryptamine receptor 7 (Q14A50)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Additional graphs summarizing 5,644 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
40 adverse events reported
View more details