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Butorphanol
Stadol (butorphanol) is a small molecule pharmaceutical. Butorphanol was first approved as Stadol preservative free on 1982-01-01. It is used to treat pain in the USA. The pharmaceutical is active against mu-type opioid receptor and kappa-type opioid receptor.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
signs and symptoms pathological conditionsD013568
psychological phenomenaD011579
musculoskeletal and neural physiological phenomenaD055687
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Butorphanol tartrate
Tradename
Company
Number
Date
Products
STADOL PRESERVATIVE FREEBristol Myers SquibbN-017857 DISCN1982-01-01
2 products, RLD
STADOLBristol Myers SquibbN-017857 DISCN1982-01-01
1 products, RLD
STADOLBristol Myers SquibbN-019890 DISCN1991-12-12
1 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
painEFO_0003843D010146R52
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N02: Analgesics
— N02A: Opioid analgesics
— N02AF: Morphinan derivatives, opiod analgesics
— N02AF01: Butorphanol
HCPCS
Code
Description
J0595
Injection, butorphanol tartrate, 1 mg
S0012
Butorphanol tartrate, nasal spray, 25 mg
Clinical
Clinical Trials
4 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
VaginitisD014627EFO_0005757N76——1——1
VulvovaginitisD014848EFO_1001240N76.0——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Vulvovaginal candidiasisD002181EFO_0007543B37.3—1——12
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameBUTORPHANOL
INNbutorphanol
Description
Butorphanol is levorphanol in which a hydrogen at position 14 of the morphinan skeleton is substituted by hydroxy and one of the hydrogens of the N-methyl group is substituted by cyclopropyl. A semi-synthetic opioid agonist-antagonist analgesic, it is used as its (S,S)-tartaric acid salt for relief or moderate to severe pain. It has a role as an opioid analgesic, a mu-opioid receptor agonist, a kappa-opioid receptor agonist and an antitussive.
Classification
Small molecule
Drug classnarcotic antagonists/agonists (morphinan derivatives)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Oc1ccc2c(c1)[C@@]13CCCC[C@@]1(O)[C@@H](C2)N(CC1CCC1)CC3
Identifiers
PDB—
CAS-ID42408-82-2
RxCUI1841
ChEMBL IDCHEMBL33986
ChEBI ID3242
PubChem CID5361092
DrugBankDB00611
UNII IDQV897JC36D (ChemIDplus, GSRS)
Target
Agency Approved
OPRM1
OPRM1
OPRK1
OPRK1
Organism
Homo sapiens
Gene name
OPRM1
Gene synonyms
MOR1
NCBI Gene ID
4988
Protein name
mu-type opioid receptor
Protein synonyms
hMOP, MOP, Mu opiate receptor, Mu opioid receptor, mu opioid receptor hMOR-1a
Uniprot ID
Q9UN57
Mouse ortholog
Oprm1 (18390)
mu-type opioid receptor (P42866)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 6,708 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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36 adverse events reported
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