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Camostat
Camostat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against serine protease 1. In addition, it is known to target transmembrane protease serine 2.
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COVID-19
Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
B: Blood and blood forming organ drugs
— B02: Antihemorrhagics
— B02A: Antifibrinolytics
— B02AB: Proteinase inhibitors, antifibrinolytic
— B02AB04: Camostat
HCPCS
No data
Clinical
Clinical Trials
23 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Covid-19D000086382U07.121351—19
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
CoronavirusD017934—11——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Severe acute respiratory syndrome-related coronavirusD045473NCBITaxon_227859—1———1
HypertensionD006973EFO_0000537I10—1———1
ObesityD009765EFO_0001073E66.9—1———1
Respiratory distress syndromeD012128EFO_1000637J80—1———1
Protein-losing enteropathiesD011504HP_0002243—1———1
Fontan procedureD018729—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Coronavirus infectionsD018352EFO_0007224B34.21————1
Healthy volunteers/patients—1————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCAMOSTAT
INNcamostat
Description
Camostat is a serine protease inhibitor. Serine protease enzymes have a variety of functions in the body, and so camostat has a diverse range of uses. Camostat is approved in Japan for the treatment of chronic pancreatitis and postoperative reflux esophagitis. The manufacturer is Ono Pharmaceutical. The drug is used in the treatment of some forms of cancer and is also effective against some viral infections, as well as inhibiting fibrosis in liver or kidney disease or pancreatitis.
Classification
Small molecule
Drug classenzyme inhibitors: proteolytic enzyme inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CN(C)C(=O)COC(=O)Cc1ccc(OC(=O)c2ccc(NC(=N)N)cc2)cc1
Identifiers
PDB—
CAS-ID59721-28-7
RxCUI—
ChEMBL IDCHEMBL590799
ChEBI ID—
PubChem CID2536
DrugBankDB13729
UNII ID0FD207WKDU (ChemIDplus, GSRS)
Target
Agency Approved
PRSS1
PRSS1
Organism
Homo sapiens
Gene name
PRSS1
Gene synonyms
TRP1, TRY1, TRYP1
NCBI Gene ID
5644
Protein name
serine protease 1
Protein synonyms
Anionic trypsin I, Anionic trypsin-I, Beta-trypsin, Cationic trypsinogen, digestive zymogen, nonfunctional trypsin 1, Pretrypsinogen I, protease, serine 1, TCR V beta 4.1, Trypsin I, Trypsin-1, trypsinogen 1, trypsinogen A
Uniprot ID
Q9HAN7
Mouse ortholog
—
—
Alternate
TMPRSS2
TMPRSS2
Organism
Homo sapiens
Gene name
TMPRSS2
Gene synonyms
PRSS10
NCBI Gene ID
7113
Protein name
transmembrane protease serine 2
Protein synonyms
epitheliasin, Serine protease 10, transmembrane protease, serine 2
Uniprot ID
O15393
Mouse ortholog
Tmprss2 (50528)
transmembrane protease serine 2 (Q9QY82)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 2,391 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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19,869 adverse events reported
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