Carbachol
Miostat (carbachol) is a small molecule pharmaceutical. Carbachol was first approved as Miostat on 1982-01-01. It is used to treat glaucoma in the USA. The pharmaceutical is active against muscarinic acetylcholine receptor M3. In addition, it is known to target muscarinic acetylcholine receptor M2, muscarinic acetylcholine receptor M5, muscarinic acetylcholine receptor M1, and muscarinic acetylcholine receptor M4.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| eye diseases | D005128 |
Trade Name
FDA
EMA
Miostat (discontinued: Carbastat)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Carbachol
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| MIOSTAT | Alcon Research | N-016968 RX | 1982-01-01 | 1 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| miostat | New Drug Application | 2020-11-09 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| glaucoma | EFO_0000516 | D005901 | H40 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N07: Other nervous system drugs in atc
— N07A: Parasympathomimetics
— N07AB: Choline esters, parasympathomimetics
— N07AB01: Carbachol
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01E: Antiglaucoma preparations and miotics
— S01EB: Parasympathomimetics, antiglaucoma preparations and miotics
— S01EB02: Carbachol
HCPCS
No data
Clinical
Clinical Trials
135 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic renal insufficiency | D051436 | N18 | 1 | — | 2 | 7 | 2 | 12 | |
| Psoriasis | D011565 | EFO_0000676 | L40 | 1 | 2 | 1 | 6 | 2 | 12 |
| Secondary hyperparathyroidism | D006962 | EFO_1001173 | — | 1 | 1 | 5 | 3 | 10 | |
| Vitamin d deficiency | D014808 | EFO_0003762 | E55 | 1 | — | 1 | 2 | 5 | 9 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | — | 2 | — | 2 | 3 | 7 |
| Diabetic nephropathies | D003928 | EFO_0000401 | — | 1 | 2 | 1 | 1 | 4 | |
| Osteoporosis | D010024 | EFO_0003882 | M81.0 | 1 | — | 1 | 1 | — | 3 |
| Proteinuria | D011507 | HP_0000093 | R80 | — | — | — | 3 | — | 3 |
| Iga glomerulonephritis | D005922 | EFO_0004194 | — | — | — | 1 | 1 | 2 | |
| Postmenopausal osteoporosis | D015663 | EFO_0003854 | 1 | — | — | 1 | — | 2 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Prostatic neoplasms | D011471 | C61 | 3 | 10 | 2 | — | 1 | 14 | |
| Hypocalcemia | D006996 | HP_0002901 | E83.51 | — | 3 | 1 | — | 2 | 6 |
| Adenomatous polyps | D018256 | D28 | — | — | 1 | — | — | 1 | |
| Angiofibroma | D018322 | EFO_1001761 | — | — | 1 | — | — | 1 | |
| Heart transplantation | D016027 | EFO_0010673 | — | — | 1 | — | — | 1 | |
| Osteopetrosis | D010022 | Q78.2 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 2 | — | — | 1 | 4 |
| Hypertension | D006973 | EFO_0000537 | I10 | 1 | 1 | — | — | 1 | 3 |
| Non-small-cell lung carcinoma | D002289 | 2 | 3 | — | — | — | 3 | ||
| Castration-resistant prostatic neoplasms | D064129 | — | 2 | — | — | — | 2 | ||
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | — | 2 | — | — | — | 2 |
| Crohn disease | D003424 | EFO_0000384 | K50 | 1 | 1 | — | — | 1 | 2 |
| Myelodysplastic syndromes | D009190 | D46 | — | 2 | — | — | — | 2 | |
| Hypoparathyroidism | D007011 | E20 | — | 1 | — | — | 1 | 2 | |
| Chronic kidney disease-mineral and bone disorder | D012080 | EFO_1001152 | N25.0 | — | 2 | — | — | — | 2 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | 2 | — | — | — | 2 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | C80 | 6 | — | — | — | — | 6 | |
| Healthy volunteers/patients | — | 1 | — | — | — | — | 1 | ||
| Cocaine-related disorders | D019970 | F14 | 1 | — | — | — | — | 1 | |
| Hypophosphatemic rickets | D063730 | E83.31 | 1 | — | — | — | — | 1 | |
| Chronic disease | D002908 | 1 | — | — | — | — | 1 | ||
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 1 | — | — | — | — | 1 |
| Endometrial neoplasms | D016889 | EFO_0004230 | 1 | — | — | — | — | 1 | |
| Uterine cervical neoplasms | D002583 | 1 | — | — | — | — | 1 | ||
| Central nervous system neoplasms | D016543 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Open-angle glaucoma | D005902 | EFO_0004190 | H40.1 | — | — | — | — | 2 | 2 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | — | — | — | 1 | 1 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | — | — | — | 1 | 1 |
| Hyperparathyroidism | D006961 | EFO_0008506 | E21.3 | — | — | — | — | 1 | 1 |
| Thyroid diseases | D013959 | HP_0000820 | E00-E07 | — | — | — | — | 1 | 1 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | — | 1 | 1 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | — | 1 | 1 |
| Lung neoplasms | D008175 | C34.90 | — | — | — | — | 1 | 1 | |
| Tobacco use disorder | D014029 | F17 | — | — | — | — | 1 | 1 | |
| Precancerous conditions | D011230 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | CARBACHOL |
| INN | carbachol |
| Description | Carbachol is an ammonium salt and a carbamate ester. It has a role as a nicotinic acetylcholine receptor agonist, a muscarinic agonist, a non-narcotic analgesic, a cardiotonic drug and a miotic. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | C[N+](C)(C)CCOC(N)=O.[Cl-] |
Identifiers
| PDB | — |
| CAS-ID | 51-83-2 |
| RxCUI | 1999 |
| ChEMBL ID | CHEMBL14 |
| ChEBI ID | 3385 |
| PubChem CID | 5831 |
| DrugBank | DB00411 |
| UNII ID | 8Y164V895Y (ChemIDplus, GSRS) |
Target
Agency Approved
Alternate
CHRM2
CHRM2
CHRM5
CHRM5
CHRM1
CHRM1
CHRM4
CHRM4
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 15,254 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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2,125 adverse events reported
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