Anlotinib
Anlotinib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target vascular endothelial growth factor receptor 2, vascular endothelial growth factor receptor 3, fibroblast growth factor receptor 1, and vascular endothelial growth factor receptor 1.
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Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
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HCPCS
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Clinical
Clinical Trials
319 clinical trials
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | C80 | 7 | 16 | 1 | — | 1 | 22 | |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 1 | 12 | 2 | — | 2 | 15 |
| Colorectal neoplasms | D015179 | 2 | 9 | 2 | — | — | 10 | ||
| Triple negative breast neoplasms | D064726 | 2 | 5 | 1 | — | — | 8 | ||
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | 1 | 6 | 1 | — | 2 | 8 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 1 | 6 | 1 | — | — | 7 |
| Endometrial neoplasms | D016889 | EFO_0004230 | 2 | 6 | 1 | — | — | 7 | |
| Uterine cervical neoplasms | D002583 | 2 | 2 | 1 | — | 1 | 5 | ||
| Thyroid neoplasms | D013964 | EFO_0003841 | — | 5 | 1 | — | — | 5 | |
| Biliary tract neoplasms | D001661 | C24.9 | — | 1 | 1 | — | — | 2 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lung neoplasms | D008175 | C34.90 | 4 | 10 | — | — | 3 | 14 | |
| Esophageal squamous cell carcinoma | D000077277 | — | 8 | — | — | 1 | 9 | ||
| Glioblastoma | D005909 | EFO_0000515 | 2 | 7 | — | — | — | 7 | |
| Nasopharyngeal neoplasms | D009303 | 2 | 7 | — | — | — | 7 | ||
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 6 | — | — | — | 6 |
| Immunotherapy | D007167 | 1 | 5 | — | — | — | 5 | ||
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 3 | 3 | — | — | — | 5 |
| Adenocarcinoma | D000230 | 2 | 3 | — | — | 1 | 5 | ||
| Female genital neoplasms | D005833 | 1 | 4 | — | — | 1 | 5 | ||
| Neoplasms by site | D009371 | — | 4 | — | — | — | 4 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Liver diseases | D008107 | EFO_0001421 | K70-K77 | 1 | — | — | — | — | 1 |
| Multiple myeloma | D009101 | C90.0 | 1 | — | — | — | — | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | ANLOTINIB |
| INN | catequentinib |
| Description | Anlotinib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target vascular endothelial growth factor receptor 2, vascular endothelial growth factor receptor 3, fibroblast growth factor receptor 1, and vascular endothelial growth factor receptor 1. |
| Classification | Small molecule |
| Drug class | tyrosine kinase inhibitors |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)ccnc2cc1OCC1(N)CC1 |
Identifiers
| PDB | — |
| CAS-ID | 1058156-90-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4303201 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | GKF8S4C432 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
KDR
KDR
FLT4
FLT4
FGFR1
FGFR1
FLT1
FLT1
Organism
Homo sapiens
Gene name
KDR
Gene synonyms
FLK1, VEGFR2
NCBI Gene ID
Protein name
vascular endothelial growth factor receptor 2
Protein synonyms
CD309, Fetal liver kinase 1, fetal liver kinase-1, FLK-1, KDR, Kinase insert domain receptor, kinase insert domain receptor (a type III receptor tyrosine kinase), Protein-tyrosine kinase receptor flk-1, soluble VEGFR2, tyrosine kinase growth factor receptor
Uniprot ID
Mouse ortholog
Kdr (16542)
vascular endothelial growth factor receptor 2 (Q8VCD0)
Variants
Clinical Variant
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Financial
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Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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152 adverse events reported
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