Celgosivir
Celgosivir is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Therapeutic Areas
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Trade Name
FDA
EMA
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
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Indications
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Agency Specific
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Patent Expiration
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ATC Codes
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HCPCS
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Clinical
Clinical Trials
9 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic hepatitis c | D019698 | EFO_0004220 | B18.2 | — | 4 | — | — | — | 4 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 1 | 2 | — | — | — | 3 |
| Dengue | D003715 | A90 | 2 | 2 | — | — | — | 2 |
Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | CELGOSIVIR |
| INN | celgosivir |
| Description | Celgosivir, in development by Migenix for the treatment of hepatitis C virus (HCV) infection, is an oral prodrug of the natural product castanospermine that inhibits alpha-glucosidase I, an enzyme that plays a critical role in viral maturation by initiating the processing of the N-linked oligosaccharides of viral envelope glycoproteins. Celgosivir is well absorbed in vitro and in vivo, and is rapidly converted to castanospermine. Celgosivir has a novel mechanism of action (preventing the glycosylation of viral proteins by the host), and demonstrates broad antiviral activity in vitro.
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| Classification | Small molecule |
| Drug class | antivirals: glucosidase inhibitors |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CCCC(=O)O[C@H]1CN2CC[C@H](O)[C@@H]2[C@@H](O)[C@@H]1O |
Identifiers
| PDB | — |
| CAS-ID | 121104-96-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2110737 |
| ChEBI ID | — |
| PubChem CID | 60734 |
| DrugBank | DB06580 |
| UNII ID | 895VG117HN (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
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Variants
Clinical Variant
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Financial
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Trends
PubMed Central
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Additional graphs summarizing 249 documents
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Safety
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Adverse Events
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0 adverse events reported
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