Cenderitide
Cenderitide is a protein pharmaceutical. It is currently being investigated in clinical studies. It is known to target atrial natriuretic peptide receptor 1 and atrial natriuretic peptide receptor 2.
Download report
Favorite
Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
12 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart failure | D006333 | EFO_0003144 | I50 | 7 | 4 | — | — | — | 10 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | 2 | 1 | — | — | — | 2 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart-assist devices | D006353 | 1 | — | — | — | — | 1 | ||
| Myocardial infarction | D009203 | EFO_0000612 | I21 | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | CENDERITIDE |
| INN | cenderitide |
| Description | Cenderitide (also known as chimeric natriuretic peptide or CD-NP) is a natriuretic peptide developed by the Mayo Clinic as a potential treatment for heart failure. Cenderitide is created by the fusion of the 15 amino acid C-terminus of dendroaspis natriuretic peptide (DNP) with the full C-type natriuretic peptide (CNP) structure both peptide which are endogenous to humans. This peptide chimera is a dual activator of the natriuretic peptide receptors NPR-A and NPR-B and therefore exhibits the natriuretic and diuretic properties of DNP, as well as the antiproliferative and antifibrotic properties of CNP.
|
| Classification | Protein |
| Drug class | peptides: atrial natriuretic type substances |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | 507289-11-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2108721 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB11777 |
| UNII ID | 9NKZ9LYZ06 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
NPR1
NPR1
NPR2
NPR2
Organism
Homo sapiens
Gene name
NPR1
Gene synonyms
ANPRA
NCBI Gene ID
Protein name
atrial natriuretic peptide receptor 1
Protein synonyms
ANP-A, ANPR-A, Atrial natriuretic peptide receptor type A, atrionatriuretic peptide receptor A, GC-A, Guanylate cyclase A, natriuretic peptide A type receptor, natriuretic peptide receptor A, natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A), NPR-A, testicular tissue protein Li 20
Uniprot ID
Mouse ortholog
Npr1 (18160)
atrial natriuretic peptide receptor 1 (P18293)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 78 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
View more details
Premium feature
Learn more about premium features at pharmakb.com
Learn more