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Cenisertib
Cenisertib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target aurora kinase B and vascular endothelial growth factor receptor 2.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
3 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Pancreatic neoplasmsD010190EFO_0003860C251————1
Hematologic neoplasmsD0193371————1
NeoplasmsD009369C801————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCENISERTIB
INNcenisertib
Description
Cenisertib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target aurora kinase B and vascular endothelial growth factor receptor 2.
Classification
Small molecule
Drug classserine/threonine kinase inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Cc1cc(Nc2ncc(F)c(NC3C4C=CC(C4)C3C(N)=O)n2)ccc1N1CCN(C)CC1
Identifiers
PDB—
CAS-ID871357-89-0
RxCUI—
ChEMBL IDCHEMBL1967878
ChEBI ID—
PubChem CID49830398
DrugBank—
UNII ID5277GPA358 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
AURKB
AURKB
KDR
KDR
Organism
Homo sapiens
Gene name
AURKB
Gene synonyms
AIK2, AIM1, AIRK2, ARK2, STK1, STK12, STK5
NCBI Gene ID
9212
Protein name
aurora kinase B
Protein synonyms
AIM-1, ARK-2, Aurora 1, aurora kinase B-Sv1, aurora kinase B-Sv2, Aurora- and IPL1-like midbody-associated protein 1, aurora- and Ipl1-like midbody-associated protein 1 homolog, aurora-1, aurora-B, Aurora-related kinase 2, Aurora/IPL1-related kinase 2, protein phosphatase 1, regulatory subunit 48, serine/threonine kinase 12, Serine/threonine-protein kinase 12, Serine/threonine-protein kinase 5, Serine/threonine-protein kinase aurora-B, STK-1
Uniprot ID
Q96GD4
Mouse ortholog
Aurkb (20877)
aurora kinase B (Q8C6C1)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 11 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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