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Cerdulatinib
Cerdulatinib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target tyrosine-protein kinase JAK1, NUAK family SNF1-like kinase 1, non-receptor tyrosine-protein kinase TYK2, tyrosine-protein kinase SYK, mitogen-activated protein kinase kinase kinase 9, macrophage colony-stimulating factor 1 receptor, tyrosine-protein kinase JAK2, tyrosine-protein kinase JAK3, and serine/threonine-protein kinase 4.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
4 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Large-cell lymphoma anaplasticD017728C84.6—11——1
T-cell lymphoma peripheralD016411C84.9—11——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
B-cell chronic lymphocytic leukemiaD015451C91.111———1
T-cell lymphomaD01639911———1
Hodgkin diseaseD006689C8111———1
Follicular lymphomaD008224C8211———1
VitiligoD014820EFO_0004208L80—1———1
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Non-hodgkin lymphomaD008228C85.9————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCERDULATINIB
INNcerdulatinib
Description
Cerdulatinib is a small molecule SYK/JAK kinase inhibitor in development for treatment of hematological malignancies. It has lowest nM IC50 values against TYK2, JAK1, JAK2, JAK3, FMS, and SYK.
Classification
Small molecule
Drug classtyrosine kinase inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCS(=O)(=O)N1CCN(c2ccc(Nc3ncc(C(N)=O)c(NC4CC4)n3)cc2)CC1
Identifiers
PDB—
CAS-ID1198300-79-6
RxCUI—
ChEMBL IDCHEMBL4116008
ChEBI ID—
PubChem CID44595079
DrugBankDB15499
UNII IDD1LXQ45S1O (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
JAK1
JAK1
NUAK1
NUAK1
TYK2
TYK2
SYK
SYK
MAP3K9
MAP3K9
CSF1R
CSF1R
JAK2
JAK2
JAK3
JAK3
STK4
STK4
Organism
Homo sapiens
Gene name
JAK1
Gene synonyms
JAK1A, JAK1B
NCBI Gene ID
3716
Protein name
tyrosine-protein kinase JAK1
Protein synonyms
JAK-1, Janus kinase 1
Uniprot ID
Q9UD26
Mouse ortholog
Jak1 (16451)
tyrosine-protein kinase JAK1 (P52332)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 210 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1 adverse events reported
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