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Cetrotide(cetrorelix)
Cetrotide (cetrorelix) is a protein pharmaceutical. Cetrorelix was first approved as Cetrotide on 1999-04-12. It is used to treat ovarian hyperstimulation syndrome in the USA. It has been approved in Europe to treat ovulation and ovulation induction. The pharmaceutical is active against gonadotropin-releasing hormone receptor.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
urogenital diseasesD000091642
endocrine system diseasesD004700
therapeuticsD013812
investigative techniquesD008919
reproductive and urinary physiological phenomenaD012101
Trade Name
FDA
EMA
Cetrotide (generic drugs available since 2022-08-12)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Cetrorelix acetate
Tradename
Company
Number
Date
Products
CETROTIDEEMD SeronoN-021197 RX2000-08-11
1 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
cetrorelixANDA2022-10-03
cetrotideNew Drug Application2018-09-24
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
ovarian hyperstimulation syndrome—D016471—
Agency Specific
FDA
EMA
Expiration
Code
CETRORELIX ACETATE, CETRORELIX ACETATE, AKORN
2023-04-22CGT
Patent Expiration
No data
ATC Codes
H: Systemic hormonal preparations, excl. sex hormones and insulins
— H01: Pituitary and hypothalamic hormones and analogues
— H01C: Hypothalamic hormones
— H01CC: Anti-gonadotropin-releasing hormones
— H01CC02: Cetrorelix
HCPCS
No data
Clinical
Clinical Trials
60 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
InfertilityD007246EFO_000054511311621
Fertilization in vitroD005307———7—7
Polycystic ovary syndromeD011085EFO_0000660E28.2——2316
Intracytoplasmic sperm injectionsD020554———5—5
Left ventricular dysfunctionD018487———1—1
Heart diseasesD006331EFO_0003777I51.9———1—1
LeiomyomaD007889HP_0000131D25———1—1
Ovarian cystsD010048HP_0000138N83.1———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Female infertilityD007247EFO_0008560N97——4——4
Ovarian hyperstimulation syndromeD016471111—24
Prostatic hyperplasiaD011470EFO_0000284N40——3——3
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Rheumatoid arthritisD001172EFO_0000685M06.9—1———1
EndometriosisD004715EFO_0001065N80—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
AgingD000375GO_0007568R41.811————1
MenopauseD008593EFO_0003922N951————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
ObesityD009765EFO_0001073E66.9————22
Healthy volunteers/patients—————11
Type 1 diabetes mellitusD003922EFO_0001359E10————11
Ectopic pregnancyD011271O00————11
PremenopauseD017697————11
FertilityD005298————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCETRORELIX
INNcetrorelix
Description
Cetrorelix is a synthetic ten-membered oligopeptide comprising N-acetyl-3-(naphthalen-2-yl)-D-alanyl, 4-chloro-D-phenylalanyl, 3-(pyridin-3-yl)-D-alanyl, L-seryl, L-tyrosyl, N(5)-carbamoyl-D-ornithyl, L-leucyl, L-arginyl, L-prolyl, and D-alaninamide residues coupled in sequence. A gonadotrophin-releasing hormone (GnRH) antagonist, it is used for treatment of infertility and of hormone-sensitive cancers of the prostate and breast. It has a role as a GnRH antagonist and an antineoplastic agent.
Classification
Protein
Drug classhormone-release inhibiting peptides
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O
Identifiers
PDB—
CAS-ID120287-85-6
RxCUI68147
ChEMBL IDCHEMBL1200490
ChEBI ID59224
PubChem CID25074887
DrugBankDB00050
UNII IDOON1HFZ4BA (ChemIDplus, GSRS)
Target
Agency Approved
GNRHR
GNRHR
Organism
Homo sapiens
Gene name
GNRHR
Gene synonyms
GRHR
NCBI Gene ID
2798
Protein name
gonadotropin-releasing hormone receptor
Protein synonyms
gnRH receptor, gnRH-R, gonadotropin-releasing hormone (type 1) receptor 1, leutinizing hormone releasing horomone receptor, leutinizing-releasing hormone receptor, luliberin receptor, type I GnRH receptor
Uniprot ID
Q92644
Mouse ortholog
Gnrhr (14715)
gonadotropin-releasing hormone receptor (Q61611)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 2,100 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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191 adverse events reported
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