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Cevimeline
Evoxac (cevimeline) is a small molecule pharmaceutical. Cevimeline was first approved as Evoxac on 2000-01-11. It is used to treat xerostomia in the USA. It is known to target muscarinic acetylcholine receptor M2, muscarinic acetylcholine receptor M1, muscarinic acetylcholine receptor M4, and muscarinic acetylcholine receptor M3.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
stomatognathic diseasesD009057
Trade Name
FDA
EMA
Evoxac (generic drugs available since 2013-07-08)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Cevimeline hydrochloride
Tradename
Company
Number
Date
Products
EVOXACCosette Pharmaceuticals N-020989 RX2000-01-11
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
cevimeline hydrochlorideANDA2023-05-03
evoxacNew Drug Application2022-06-21
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
xerostomia—D014987K11.7
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N07: Other nervous system drugs in atc
— N07A: Parasympathomimetics
— N07AX: Other parasympathomimetics in atc
— N07AX03: Cevimeline
HCPCS
No data
Clinical
Clinical Trials
1 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Pain managementD059408———1—1
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCEVIMELINE
INNcevimeline
Description
Cevimeline (trade name Evoxac) is a synthetic analog of the natural alkaloid muscarine with a particular agonistic effect on M1 and M3 receptors. It is used in the treatment of dry mouth and Sjögren's syndrome.
Classification
Small molecule
Drug classcholinergic agonists (arecoline derivatives used in treatment of Alzheimer's disease
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC1OC2(CS1)CN1CCC2CC1
Identifiers
PDB—
CAS-ID107233-08-9
RxCUI44281
ChEMBL IDCHEMBL168815
ChEBI ID—
PubChem CID2684
DrugBankDB00185
UNII IDK9V0CDQ56E (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
CHRM2
CHRM2
CHRM1
CHRM1
CHRM4
CHRM4
CHRM3
CHRM3
Organism
Homo sapiens
Gene name
CHRM2
Gene synonyms
NCBI Gene ID
1129
Protein name
muscarinic acetylcholine receptor M2
Protein synonyms
7TM receptor, acetylcholine receptor, muscarinic 2, muscarinic M2 receptor
Uniprot ID
Q9P1X9
Mouse ortholog
Chrm2 (243764)
muscarinic acetylcholine receptor M2 (Q9ERZ4)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 474 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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180 adverse events reported
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