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Chenodiol
Chenix (chenodiol) is a small molecule pharmaceutical. Chenodiol was first approved as Chenix on 1983-07-28. The pharmaceutical is active against bile acid receptor. In addition, it is known to target G-protein coupled bile acid receptor 1 and fMet-Leu-Phe receptor.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Chenodiol
Tradename
Company
Number
Date
Products
CHENIXLeadiant BiosciencesN-018513 DISCN1983-07-28
1 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
chenodiolANDA2023-04-27
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
— A05: Bile and liver therapy drugs
— A05A: Bile therapy drugs
— A05AA: Bile acids and derivatives for bile therapy
— A05AA01: Chenodeoxycholic acid
HCPCS
No data
Clinical
Clinical Trials
15 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
ObesityD009765EFO_0001073E66.9———314
CholelithiasisD002769EFO_0004799K80———1—1
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Cerebrotendinous xanthomatosisD019294—1——23
Hereditary spastic paraplegiaD015419EFO_0000529G11.4—1———1
Irritable bowel syndromeD043183EFO_0000555K58—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
EcholocationD0044551————1
Hyperlipoproteinemia type ivD006953Orphanet_413E78.11————1
Metabolic syndromeD024821EFO_0000195E88.811————1
Familial combined hyperlipidemiaD006950E78.491————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Type 2 diabetes mellitusD003924EFO_0001360E11————11
Zellweger syndromeD015211Orphanet_912E71.510————11
Infantile refsum diseaseD052919Orphanet_772G60.1————11
AdrenoleukodystrophyD000326Orphanet_43E71.52————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCHENODIOL
INNchenodeoxycholic acid
Description
Chenodeoxycholic acid is a dihydroxy-5beta-cholanic acid that is (5beta)-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 7 respectively. It has a role as a human metabolite and a mouse metabolite. It is a bile acid, a dihydroxy-5beta-cholanic acid and a C24-steroid. It is a conjugate acid of a chenodeoxycholate.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O
Identifiers
PDB6HL1
CAS-ID474-25-9
RxCUI2323
ChEMBL IDCHEMBL240597
ChEBI ID16755
PubChem CID10133
DrugBankDB06777
UNII ID0GEI24LG0J (ChemIDplus, GSRS)
Target
Agency Approved
NR1H4
NR1H4
Organism
Homo sapiens
Gene name
NR1H4
Gene synonyms
BAR, FXR, HRR1, RIP14
NCBI Gene ID
9971
Protein name
bile acid receptor
Protein synonyms
farnesoid X nuclear receptor, Farnesoid X-activated receptor, Farnesol receptor HRR-1, Nuclear receptor subfamily 1 group H member 4, Retinoid X receptor-interacting protein 14, RXR-interacting protein 14
Uniprot ID
Q96RI1
Mouse ortholog
Nr1h4 (20186)
bile acid receptor (Q60641)
Alternate
GPBAR1
GPBAR1
FPR1
FPR1
Organism
Homo sapiens
Gene name
GPBAR1
Gene synonyms
TGR5
NCBI Gene ID
151306
Protein name
G-protein coupled bile acid receptor 1
Protein synonyms
BG37, G-protein coupled bile acid receptor BG37, G-protein coupled receptor GPCR19, hBG37, hGPCR19, M-BAR, membrane bile acid receptor, Membrane-type receptor for bile acids
Uniprot ID
Q8TDU6
Mouse ortholog
Gpbar1 (227289)
G-protein coupled bile acid receptor 1 (Q80SS6)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 7,280 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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29,730 adverse events reported
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