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Chlordiazepoxide
A-poxide, Chlordiazachel, Librax, Librelease, Libritabs, Librium, Limbitrol, Lygen, Menrium (chlordiazepoxide) is a small molecule pharmaceutical. Chlordiazepoxide was first approved as Limbitrol on 1982-01-01. It is used to treat alcohol withdrawal delirium and anxiety disorders in the USA. It is known to target thyrotropin-releasing hormone receptor.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
chemically-induced disordersD064419
mental disordersD001523
Trade Name
FDA
EMA
Combinations
Librax (generic drugs available since 1982-01-01, discontinued: Limbitrol, Menrium)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Amitriptyline hydrochloride
+
Chlordiazepoxide
Tradename
Company
Number
Date
Products
LIMBITROLChartwell PharmaceuticalsN-016949 DISCN1982-01-01
1 products, RLD
LIMBITROL DSChartwell PharmaceuticalsN-016949 DISCN1982-01-01
1 products, RLD
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Chlordiazepoxide
Tradename
Company
Number
Date
Products
LIBRELEASEBausch Health CompaniesN-017813 DISCN1983-09-12
1 products
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Chlordiazepoxide
+
Estrogens
+
esterified
Tradename
Company
Number
Date
Products
MENRIUM 5-2RocheN-014740 DISCN1982-01-01
1 products
MENRIUM 5-4RocheN-014740 DISCN1982-01-01
1 products
MENRIUM 10-4RocheN-014740 DISCN1982-01-01
1 products
Hide discontinued
Chlordiazepoxide hydrochloride
Tradename
Company
Number
Date
Products
LIBRIUMBausch Health CompaniesN-012301 DISCN1982-01-01
1 products
LIBRIUMBausch Health CompaniesN-012249 DISCN1982-01-01
3 products, RLD
Hide discontinued
Chlordiazepoxide hydrochloride
+
Clidinium bromide
Tradename
Company
Number
Date
Products
LIBRAXBausch Health CompaniesN-012750 RX1982-01-01
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
chlordiazepoxide hydrochlorideANDA2023-06-09
libraxNew Drug Application2021-02-03
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
alcohol withdrawal deliriumEFO_1000800D000430—
anxiety disordersEFO_0006788D001008F41.1
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N05: Psycholeptics
— N05B: Anxiolytics
— N05BA: Benzodiazepine derivative anxiolytics
— N05BA02: Chlordiazepoxide
HCPCS
Code
Description
J1990
Injection, chlordiazepoxide hcl, up to 100 mg
Clinical
Clinical Trials
1 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCHLORDIAZEPOXIDE
INNchlordiazepoxide
Description
7-chloro-4-hydroxy-N-methyl-5-phenyl-3H-1,4-benzodiazepin-2-imine is a benzodiazepine.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CNC1=Nc2ccc(Cl)cc2C(c2ccccc2)=[N+]([O-])C1
Identifiers
PDB—
CAS-ID58-25-3
RxCUI2356
ChEMBL IDCHEMBL451
ChEBI ID3611
PubChem CID2712
DrugBankDB00475
UNII ID6RZ6XEZ3CR (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
TRHR
TRHR
Organism
Homo sapiens
Gene name
TRHR
Gene synonyms
NCBI Gene ID
7201
Protein name
thyrotropin-releasing hormone receptor
Protein synonyms
Thyroliberin receptor
Uniprot ID
Q2M339
Mouse ortholog
Trhr (22045)
thyrotropin-releasing hormone receptor (P21761)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 5,823 documents
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Safety
Black-box Warning
Black-box warning for: Chlordiazepoxide hydrochloride, Librax
Adverse Events
Top Adverse Reactions
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537 adverse events reported
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