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Chloroprocaine
Clorotekal, Iheezo, Nesacaine, Nesacaine-mpf (chloroprocaine) is a small molecule pharmaceutical. Chloroprocaine was first approved as Nesacaine on 1982-01-01. It is used to treat pain in the USA. It is known to target ryanodine receptor 1 and ryanodine receptor 2.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
signs and symptoms pathological conditionsD013568
psychological phenomenaD011579
musculoskeletal and neural physiological phenomenaD055687
Trade Name
FDA
EMA
Clorotekal, Iheezo, Nesacaine, Nesacaine-mpf (generic drugs available since 1998-09-09)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Chloroprocaine hydrochloride
Tradename
Company
Number
Date
Products
CLOROTEKALB. Braun MedicalN-208791 RX2017-09-26
1 products, RLD
NESACAINE-MPFFresenius KabiN-009435 RX1996-05-02
2 products, RLD, RS
NESACAINEFresenius KabiN-009435 RX1982-01-01
2 products, RLD
IHEEZOHarrowN-216227 RX2022-09-27
1 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
clorotekalNew Drug Application2020-12-04
iheezoNew Drug Application2022-09-27
nesacaineNew Drug Application2022-12-29
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
painEFO_0003843D010146R52
Agency Specific
FDA
EMA
Expiration
Code
CHLOROPROCAINE HYDROCHLORIDE, IHEEZO, HARROW EYE
2025-09-27NP
Patent Expiration
Patent
Expires
Flag
FDA Information
Chloroprocaine Hydrochloride, Iheezo, Harrow Eye
107922712038-09-15DPU-3457
Chloroprocaine Hydrochloride, Clorotekal, B Braun Medical Inc
95046662033-12-11DP
89694122026-09-05DPU-2609
ATC Codes
N: Nervous system drugs
— N01: Anesthetics
— N01B: Local anesthetics
— N01BA: Esters of aminobenzoic acid for local anesthesia
— N01BA04: Chloroprocaine
HCPCS
Code
Description
J2400
Injection, chloroprocaine hydrochloride, per 30 ml
Clinical
Clinical Trials
38 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—10——1—11
Respiratory tract infectionsD012141J06.9—131—4
BronchitisD001991J40———123
AsthmaD001249EFO_0000270J45———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
CoughD003371HP_0012735R051—2—14
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeuralgiaD009437EFO_0009430—1———1
Hiv infectionsD015658EFO_0000764B20—1———1
SinusitisD012852EFO_0007486J32—1———1
Common coldD003139EFO_0007214J00—1———1
Communicable diseasesD003141—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Therapeutic equivalencyD0138101————1
Mucociliary clearanceD0090791————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PneumoniaD011014EFO_0003106J18————11
Lung diseasesD008171EFO_0003818J98.4————11
Pulmonary fibrosisD011658J84.10————11
Back painD001416HP_0003418M54————11
InfectionsD007239EFO_0000544————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCHLOROPROCAINE
INNchloroprocaine
Description
Chloroprocaine is procaine in which one of the hydrogens ortho- to the carboxylic acid group is substituted by chlorine. It is used as its monohydrochloride salt as a local anaesthetic, particularly for oral surgery. It has the advantage over lidocaine of constricting blood vessels, so reducing bleeding. It has a role as a local anaesthetic, a peripheral nervous system drug and a central nervous system depressant. It is a benzoate ester and a member of monochlorobenzenes. It is functionally related to a 2-diethylaminoethanol and a 4-amino-2-chlorobenzoic acid.
Classification
Small molecule
Drug classlocal anesthetics
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCN(CC)CCOC(=O)c1ccc(N)cc1Cl
Identifiers
PDB—
CAS-ID133-16-4
RxCUI20859
ChEMBL IDCHEMBL1179047
ChEBI ID3636
PubChem CID8612
DrugBankDB01161
UNII ID5YVB0POT2H (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
RYR1
RYR1
RYR2
RYR2
Organism
Homo sapiens
Gene name
RYR1
Gene synonyms
RYDR
NCBI Gene ID
6261
Protein name
ryanodine receptor 1
Protein synonyms
central core disease of muscle, protein phosphatase 1, regulatory subunit 137, ryanodine receptor 1 (skeletal), sarcoplasmic reticulum calcium release channel, Skeletal muscle calcium release channel, Skeletal muscle ryanodine receptor, Skeletal muscle-type ryanodine receptor, Type 1 ryanodine receptor, type 1-like ryanodine receptor
Uniprot ID
Q9P1U4
Mouse ortholog
Ryr1 (20190)
ryanodine receptor 1 (Q99JF9)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 391 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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17 adverse events reported
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