Chlorothiazide
Aldoclor, Diupres, Diuril (chlorothiazide) is a small molecule pharmaceutical. Chlorothiazide was first approved as Diuril on 1982-01-01. It is used to treat edema, glomerulonephritis, heart failure, hypertension, and liver cirrhosis amongst others in the USA. The pharmaceutical is active against solute carrier family 12 member 3.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| digestive system diseases | D004066 |
| urogenital diseases | D000091642 |
| cardiovascular diseases | D002318 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
Diuril (generic drugs available since 2009-10-16)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| chlorothiazide | ANDA | 2023-05-31 |
| diuril | New Drug Application | 2021-11-01 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| edema | — | D004487 | R60.9 |
| glomerulonephritis | — | D005921 | N05 |
| heart failure | EFO_0003144 | D006333 | I50 |
| hypertension | EFO_0000537 | D006973 | I10 |
| liver cirrhosis | EFO_0001422 | D008103 | K74.0 |
| nephrotic syndrome | EFO_0004255 | D009404 | N04 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C03: Diuretics
— C03A: Low-ceiling diuretics, thiazides
— C03AA: Thiazides, plain
— C03AA04: Chlorothiazide
— C03AB: Thiazides and potassium in combination
— C03AB04: Chlorothiazide and potassium
— C03AH: Thiazides, combinations with psycholeptics and/or analgesics
— C03AH01: Chlorothiazide, combinations
HCPCS
Code | Description |
|---|---|
| J1205 | Injection, chlorothiazide sodium, per 500 mg |
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | CHLOROTHIAZIDE |
| INN | chlorothiazide |
| Description | Chlorothiazide is 4H-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position is substituted by chlorine and that at position 7 is substituted by a sulfonamide group. A diuretic, it is used for treatment of oedema and hypertension. It has a role as a diuretic and an antihypertensive agent. |
| Classification | Small molecule |
| Drug class | diuretics (thiazide derivatives) |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | NS(=O)(=O)c1cc2c(cc1Cl)N=CNS2(=O)=O |
Identifiers
| PDB | — |
| CAS-ID | 58-94-6 |
| RxCUI | 2396 |
| ChEMBL ID | CHEMBL842 |
| ChEBI ID | 3640 |
| PubChem CID | 2720 |
| DrugBank | DB00880 |
| UNII ID | 77W477J15H (ChemIDplus, GSRS) |
Target
Agency Approved
SLC12A3
SLC12A3
Organism
Homo sapiens
Gene name
SLC12A3
Gene synonyms
NCC, TSC
NCBI Gene ID
Protein name
solute carrier family 12 member 3
Protein synonyms
Na-Cl cotransporter, Na-Cl symporter, NaCl electroneutral thiazide-sensitive cotransporter, NCC, sodium-chloride co-transporter, solute carrier family 12 (sodium/chloride transporter), member 3, thiazide-sensitive Na-Cl cotransporter, Thiazide-sensitive sodium-chloride cotransporter
Uniprot ID
Mouse ortholog
Slc12a3 (20497)
solute carrier family 12 member 3 (P59158)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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207 adverse events reported
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